ATTENUATION OF BENZODIAZEPINE-INDUCED PASSIVE-AVOIDANCE DEFICIT BY POST-TRAINING ADMINISTRATION OF MUSCIMOL - INTERACTION WITH THE CHOLINERGIC NEURONAL SYSTEM

被引：10

作者：

NABESHIMA, T ^{[1
]}

TOHYAMA, K ^{[1
]}

ICHIHARA, K ^{[1
]}

KAMEYAMA, T ^{[1
]}

机构：

[1] NAGOYA UNIV,SCH MED,DEPT HOSP PHARM,NAGOYA,AICHI 466,JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 182卷 / 03期

关键词：

(Mouse); Acetylcholine receptor antagonist; Chlordiazepoxide; Cholinergic neuronal system; GABA receptor agonists; GABA receptor antagonists; Passive avoidance response;

D O I：

10.1016/0014-2999(90)90055-B

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We examined the involvement of GABAergic neuronal systems in benzodiazepine-induced passive avoidance deficit. Chlordiazepoxide impaired the passive avoidance response dose dependently when it was given prior to training. Post-training administration of muscimol improved the performance of chlordiazepoxide-pretreated mice. The effects of muscimol were antagonized completely by the GABAA antagonist, bicuculline, and the muscarinic acetycholine receptor antaagonist, scopolamine, but not by the benzodiazepine receptor antagonist, flumazenil, when the latter was administered immediately after training. It appears from these results that the GABAergic neuronal system plays an important role in the benzodiazepine-induced passive avoidance deficit by interacting with the cholinergic neuronal system. © 1990.

引用

页码：555 / 560

页数：6

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