CLQ METABOLISM IN ULCERATIVE-COLITIS AND CROHNS-DISEASE

被引:16
作者
POTTER, BJ
HODGSON, HJF
MEE, AS
JEWELL, DP
机构
关键词
D O I
10.1136/gut.20.11.1012
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The metabolism of pure radioiodine labelled C1q has been observed in five patients with ulcerative colitis, five patients with Crohn's disease, and in five control subjects. Both the fractional catabolic rate and the synthesis rate of C1q were increased in the five patients with Crohn's disease and in four of the five patients with ulcerative colitis. The fifth patient was in remission and had a normal synthesis rate. These results support the hypothesis that complement activation plays a role in the pathogenesis of these disease states and that the increased complement activation is primarily via the classical pathway.
引用
收藏
页码:1012 / 1019
页数:8
相关论文
共 25 条
[1]  
BERSON SA, 1957, FED PROC, V16, P135
[2]   HIGH-RESOLUTION DENSITY GRADIENT SEDIMENTATION ANALYSIS [J].
BRITTEN, RJ ;
ROBERTS, RB .
SCIENCE, 1960, 131 (3392) :32-33
[3]   SHORT-TERM COURSE AND PROGNOSIS OF CROHNS-DISEASE [J].
DEDOMBAL, FT ;
BURTON, IL ;
CLAMP, SE ;
GOLIGHER, JC .
GUT, 1974, 15 (06) :435-443
[4]  
DOE WF, 1973, LANCET, V1, P402
[5]   ALBUMIN STANDARDS AND MEASUREMENT OF SERUM ALBUMIN WITH BROMCRESOL GREEN [J].
DOUMAS, BT ;
WATSON, WA ;
BIGGS, HG .
CLINICA CHIMICA ACTA, 1971, 31 (01) :87-&
[6]   INHIBITION OF COMPLEMENT-DEPENDENT LYMPHOCYTE ROSETTE FORMATION - POSSIBLE TEST FOR ACTIVATED COMPLEMENT PRODUCTS [J].
EZER, G ;
HAYWARD, AR .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1974, 4 (02) :148-150
[7]  
HODGSON HJF, 1977, CLIN EXP IMMUNOL, V28, P490
[8]  
HODGSON HJF, 1977, CLIN EXP IMMUNOL, V29, P187
[9]   HUMORAL IMMUNE SYSTEM IN INFLAMMATORY BOWEL-DISEASE .1. COMPLEMENT LEVELS [J].
HODGSON, HJF ;
POTTER, BJ ;
JEWELL, DP .
GUT, 1977, 18 (09) :749-753
[10]   IMMUNE-COMPLEX MEDIATED COLITIS IN RABBITS - EXPERIMENTAL-MODEL [J].
HODGSON, HJF ;
POTTER, BJ ;
SKINNER, J ;
JEWELL, DP .
GUT, 1978, 19 (03) :225-232