ANTI-IL-5 MONOCLONAL-ANTIBODY INHIBITS ALLERGIC LATE PHASE BRONCHIAL EOSINOPHILIA IN GUINEA-PIGS - A THERAPEUTIC APPROACH

被引：116

作者：

CHAND, N

HARRISON, JE

ROONEY, S

PILLAR, J

JAKUBICKI, R

NOLAN, K

DIAMANTIS, W

SOFIA, RD

机构：

[1] Wallace Laboratories, Division of Carter-Wallace, Inc., Cranbury

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 211卷 / 01期

关键词：

ANTI-IL-5 MONOCLONAL BODY; BRONCHOALVEOLAR EOSINOPHILIA; ASTHMA MODEL (GUINEA PIG); (THERAPEUTIC APPROACH);

D O I：

10.1016/0014-2999(92)90273-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this study the effect of purified rat anti-mouse IL-5 monoclonal antibody on aeroallergen-induced infiltration of eosinophils in the bronchoalveolar lavage fluid of guinea pigs was studied. The i.p. injection of anti-IL-5 antibody 4 h after aerollagen challenge inhibited eosinophil infiltration in a dose-dependent fashion. The resulting ED50 was 10 (3.4-32.8) mu-g/kg. The clinical therapeutic usefulness of anti-IL-5 or anti-IL-5-producing cells in asthma/allergy treatment remains to be an intriguing possibility.

引用

页码：121 / 123

页数：3

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