INACTIVATION OF THE ELASTASE INHIBITORY ACTIVITY OF ALPHA-1 ANTITRYPSIN IN FRESH SAMPLES OF SYNOVIAL-FLUID FROM PATIENTS WITH RHEUMATOID-ARTHRITIS

被引：51

作者：

CHIDWICK, K ^{[1
]}

WINYARD, PG ^{[1
]}

ZHANG, Z ^{[1
]}

FARRELL, AJ ^{[1
]}

BLAKE, DR ^{[1
]}

机构：

[1] LONDON HOSP,COLL MED,INFLAMMAT GRP,ARTHRIT & RHEUMATISM COUNCIL BLDG,25-29 ASHFIELD ST,LONDON E1 1AD,ENGLAND

来源：

ANNALS OF THE RHEUMATIC DISEASES | 1991年 / 50卷 / 12期

关键词：

D O I：

10.1136/ard.50.12.915

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The proteinase inhibitory ability of alpha-1 antitrypsin was measured in 23 samples of rheumatoid arthritis synovial fluid, eight osteoarthritic synovial fluids and nine normal control serum samples. For each sample a detailed kinetic analysis was performed with porcine pancreatic elastase as the target proteinase. Samples were stored for less than 24 hours at 4-degrees-C before analysis, which does not significantly alter the proportion of inactive alpha-1 antitrypsin. In rheumatoid synovial fluid the elastase inhibitory ability was disproportionately depressed relative to the immunochemically determined concentrations of alpha-1 antitrypsin.

引用

页码：915 / 916

页数：2

共 11 条

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