THE SOLUBILITY OF ANTIBIOTIC AND CORTICOSTEROID COMBINATIONS

被引：13

作者：

LEE, BL ^{[1
]}

MATOBA, AY ^{[1
]}

OSATO, MS ^{[1
]}

ROBINSON, NM ^{[1
]}

机构：

[1] BAYLOR COLL MED,CULLEN EYE INST,6501 FANNIN ST,NC-200,HOUSTON,TX 77030

来源：

AMERICAN JOURNAL OF OPHTHALMOLOGY | 1992年 / 114卷 / 02期

关键词：

D O I：

10.1016/S0002-9394(14)73987-X

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The use of collagen shields soaked in various combinations of medications has been advocated to enhance drug delivery to the cornea. Recently, severe corneal toxicity associated with aggregate formation in mixtures of gentamicin and methylprednisolone prompted our study of the effect of drug concentration, pH, and temperature on the solubility of several antibiotic and corticosteroid formulations commonly used to treat ocular disease. Selected combinations of cefazolin, vancomycin, tobramycin, gentamicin, methylprednisolone, and dexamethasone were evaluated. Mixtures of tobramycin and vancomycin produced no precipitates, but many spheroid aggregates were seen when methylprednisolone and gentamicin were combined. Although the effects of precipitate formation on drug bioavailability and toxicity have not been fully determined, until such information is available, the use of combinations of drugs that remain in solution during administration is recommended.

引用

页码：212 / 215

页数：4

共 7 条

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