THE RELATIONSHIP BETWEEN THE CHEMICAL STRUCTURES AND MUTAGENIC SPECIFICITIES OF THE DNA LESIONS FORMED BY CHEMICAL AND PHYSICAL MUTAGENS

被引：20

作者：

ESSIGMANN, JM

WOOD, ML

机构：

[1] Massachusetts Institute of Technology, Cambridge

来源：

TOXICOLOGY LETTERS | 1993年 / 67卷 / 1-3期

关键词：

SITE-SPECIFIC MUTAGENESIS; ALKYLATING AGENTS AROMATIC AMINES; RADIATION; DNA ADDUCTS;

D O I：

10.1016/0378-4274(93)90044-X

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The mutagenic activities of radiation, alkylating agents, and aromatic amines and amides are examined from the perspective of relating the observed patterns of mutagenesis with the structures of the premutagenic DNA lesions. The general approach taken to establish such relationships has involved the construction of viral or plasmid genomes containing specific DNA adducts. The in vivo replication of such site-specifically modified genomes results in the induction of mutations, which are characterized by DNA sequencing. It is found that the mutation types that arise in these simple systems often match those occurring in tumors produced in mammals exposed intentionally or unintentionally to carcinogenic agents.

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页码：29 / 39

页数：11

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共 53 条

[1] SOS-DEPENDENT REPLICATION PAST A SINGLE TRANS-SYN T-T CYCLOBUTANE DIMER GIVES A DIFFERENT MUTATION SPECTRUM AND INCREASED ERROR RATE COMPARED WITH REPLICATION PAST THIS LESION IN UNINDUCED CELLS [J].

BANERJEE, SK ;

BORDEN, A ;

CHRISTENSEN, RB ;

LECLERC, JE ;

LAWRENCE, CW .

JOURNAL OF BACTERIOLOGY, 1990, 172 (04) :2105-2112

[2] FREQUENCY AND SPECTRUM OF MUTATIONS PRODUCED BY A SINGLE CIS-SYN THYMINE-THYMINE CYCLOBUTANE DIMER IN A SINGLE-STRANDED VECTOR [J].

BANERJEE, SK ;

CHRISTENSEN, RB ;

LAWRENCE, CW ;

LECLERC, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (21) :8141-8145

[3] GENETIC-EFFECTS OF THYMINE GLYCOL - SITE-SPECIFIC MUTAGENESIS AND MOLECULAR MODELING STUDIES - (IONIZING-RADIATION OXIDATIVE DAMAGE HYDROXYL RADICALS) [J].

BASU, AK ;

LOECHLER, EL ;

LEADON, SA ;

ESSIGMANN, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (20) :7677-7681

[4] SITE-SPECIFICALLY MODIFIED OLIGODEOXYNUCLEOTIDES AS PROBES FOR THE STRUCTURAL AND BIOLOGICAL EFFECTS OF DNA-DAMAGING AGENTS [J].

BASU, AK ;

ESSIGMANN, JM .

CHEMICAL RESEARCH IN TOXICOLOGY, 1988, 1 (01) :1-18

[5] FORMATION AND PERSISTENCE OF ARYLAMINE DNA ADDUCTS INVIVO [J].

BELAND, FA ;

KADLUBAR, FF .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1985, 62 (OCT) :19-30

[6] THE INVIVO MUTAGENIC FREQUENCY AND SPECIFICITY OF O-6-METHYLGUANINE IN PHI-X174 REPLICATIVE FORM DNA [J].

BHANOT, OS ;

RAY, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (19) :7348-7352

[7] DNA-BINDING AND MUTATION SPECTRA OF THE CARCINOGEN N-2-AMINOFLUORENE IN ESCHERICHIA-COLI - A CORRELATION BETWEEN THE CONFORMATION OF THE PREMUTAGENIC LESION AND THE MUTATION SPECIFICITY [J].

BICHARA, M ;

FUCHS, RPP .

JOURNAL OF MOLECULAR BIOLOGY, 1985, 183 (03) :341-351

[8] UV-INDUCED MUTATION HOTSPOTS OCCUR AT DNA DAMAGE HOTSPOTS [J].

BRASH, DE ;

HASELTINE, WA .

NATURE, 1982, 298 (5870) :189-192

[9] SINGLE ADDUCT MUTAGENESIS - STRONG EFFECT OF THE POSITION OF A SINGLE ACETYLAMINOFLUORENE ADDUCT WITHIN A MUTATION HOT SPOT [J].

BURNOUF, D ;

KOEHL, P ;

FUCHS, RPP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (11) :4147-4151

[10] UVRA AND RECA MUTATIONS INHIBIT A SITE-SPECIFIC TRANSITION PRODUCED BY A SINGLE O(6)-METHYLGUANINE IN GENE-G OF BACTERIOPHAGE-PHI-X174 [J].

CHAMBERS, RW ;

SLEDZIEWSKAGOJSKA, E ;

HIRANIHOJATTI, S ;

BOROWYBOROWSKI, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (21) :7173-7177

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