HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF NAVELBINE IN MO4 MOUSE FIBROSARCOMA CELLS AND BIOLOGICAL-FLUIDS

被引：14

作者：

VANBELLE, SJP ^{[1
]}

DESMET, M ^{[1
]}

MONSAERT, C ^{[1
]}

GEERTS, F ^{[1
]}

STORME, GA ^{[1
]}

MASSART, DL ^{[1
]}

机构：

[1] VRIJE UNIV BRUSSELS,INST FARMACEUT,B-1090 BRUSSELS,BELGIUM

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1992年 / 576卷 / 02期

关键词：

D O I：

10.1016/0378-4347(92)80211-8

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A high-performance liquid chromatographic method is described for separating and determining navelbine and possible metabolites in plasma, cell culture medium and MO4 cells. Navelbine is extracted from these fluids by ion-pair extraction with sodium octylsulphate as the counter-ion at pH 3. The system uses a cyano column as the stationary phase and a mobile phase of acetonitrile-0.12 M phosphate buffer (pH 3) (60:40, v/v). Application of the method to a study of the pharmacokinetic behaviour of navelbine in MO4 mouse fibrosarcoma cells is reported.

引用

页码：351 / 357

页数：7

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