LOCALIZATION OF ANGIOTENSIN-II RECEPTOR SUBTYPES IN THE RABBIT ADRENAL AND KIDNEY

被引：29

作者：

HERBLIN, WF ^{[1
]}

DIAMOND, SM ^{[1
]}

TIMMERMANS, PBMWM ^{[1
]}

机构：

[1] DUPONT MERCK PHARMACEUT CO,DEPT MED PROD,CARDIOVASC RES SECT,WILMINGTON,DE

来源：

PEPTIDES | 1991年 / 12卷 / 03期

关键词：

ANGIOTENSIN-II RECEPTOR; KIDNEY; ADRENAL GLANDS;

D O I：

10.1016/0196-9781(91)90105-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The localization of subtypes of the angiotensin II receptor has been determined by autoradiographic techniques using iodinated angiotensin II and two nonpeptide antagonists that exhibit selective affinities. DuP 753 specifically displaces type 1 sites (AII-1) and PD123177 inhibits only type 2 sites (AII-2). The rabbit adrenal cortex contains predominately AII-1 sites and the few AII-2 sites that are present are nonuniformly distributed. In the rabbit kidney, the fibrous outer sheath contains exclusively AII-2 sites whereas the glomeruli of the renal cortex and the renal medulla exhibit only AII-1 sites.

引用

页码：581 / 584

页数：4

共 9 条

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CHIU, AT
HERBLIN, WF
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JOHNSON, AL
TIMMERMANS, PBMWM
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