MULTIPLE MEDICATION USE IN THE ELDERLY - USE OF PRESCRIPTION AND NONPRESCRIPTION DRUGS IN AN AUSTRALIAN COMMUNITY SETTING

被引:54
作者
SIMONS, LA
TETT, S
SIMONS, J
LAUCHLAN, R
MCCALLUM, J
FRIEDLANDER, Y
POWELL, I
机构
[1] UNIV NEW S WALES,SCH MED,KENSINGTON,NSW 2033,AUSTRALIA
[2] ST VINCENTS HOSP,DEPT CLIN PHARMACOL & TOXICOL,DARLINGHURST,NSW 2010,AUSTRALIA
[3] ST VINCENTS HOSP,DEPT PHARM,DARLINGHURST,NSW 2010,AUSTRALIA
[4] AUSTRALIAN NATL UNIV,NATL CTR EPIDEMIOL & POPULAT HLTH,CANBERRA,ACT 2601,AUSTRALIA
[5] HEBREW UNIV JERUSALEM,HADASSAH HOSP,DEPT SOCIAL MED,JERUSALEM,ISRAEL
关键词
D O I
10.5694/j.1326-5377.1992.tb137127.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: To document the extent of polypharmacy or multiple medication use in the elderly. Design: Cross-sectional examination of an age cohort of a community. Setting: Community-based study in Dubbo, NSW, in 1988-1989. Subjects: All non-institutionalised residents aged 60 years and over, numbering 1237 men and 1568 women. Main outcome measures: Assessment of use of prescription and non-prescription drugs, recent hospitalisation, years of education, psychosocial variables. Results: 18% of men and 25% of women were currently using three or more classes of prescription drugs. The corresponding values for two or more classes of non-prescription drugs were 29% and 44%. Of those who were using multiple prescription drugs 56% of men and 76% of women were also using multiple non-prescription drugs. In a multiple logistic model, the following possible predictors of multiple drug use were included: hospitalisation in the last six months, age, sex, depression, life satisfaction and education. Multiple prescription drug use was significantly predicted by recent hospitalisation (odds ratio [OR] = 2.40; 95% confidence interval [CI], 1.63-3.56), increasing age (e.g. 70-79 years versus 60-69 years; OR = 2.54; CI, 1.97-3.25), female sex (OR = 1.59; CI, 1.25-2.01) and increasing depression (e.g. highest tertile of depression scale versus lowest; OR = 2.52; CI, 1.84-3.42). Multiple non-prescription drug use was significantly predicted by female sex (OR = 2.38; CI, 1.95-2.92) and increasing depression (OR = 2.77; CI, 2.16-3.56). For prescription items, non-prescription items, and both categories in combination levels of use 20% above the population average have been documented. Conclusions: Polypharmacy in the elderly population appears to be predicted by recent hospitalisation, increasing age, female sex and increasing depression. There is potential for drug-drug interaction to occur, but the findings suggest target areas for preventive action.
引用
收藏
页码:242 / &
相关论文
共 13 条
[1]   TESTS FOR LINEAR TRENDS IN PROPORTIONS AND FREQUENCIES [J].
ARMITAGE, P .
BIOMETRICS, 1955, 11 (03) :375-386
[2]  
ATKIN P, 1989, AUSTRALASIAN SOC CLI
[3]  
BARER M, 1990, AUSTR PRIVATE MED CA
[4]  
DEEBLE J, 1991, 2 NAT HLTH STRAT BAC
[5]  
HELLING DK, 1986, J AM GERIATR SOC, V35, P4
[6]  
LARMOUR I, 1991, Australian Journal of Hospital Pharmacy, V21, P90
[7]   FACTORS CONTRIBUTING TO MEDICATION NONCOMPLIANCE IN ELDERLY PUBLIC-HOUSING TENANTS [J].
MURRAY, MD ;
DARNELL, J ;
WEINBERGER, M ;
MARTZ, BL .
DRUG INTELLIGENCE & CLINICAL PHARMACY, 1986, 20 (02) :146-152
[8]   THE MEASUREMENT OF LIFE SATISFACTION [J].
NEUGARTEN, BL ;
HAVIGHURST, RJ ;
TOBIN, SS .
JOURNALS OF GERONTOLOGY, 1961, 16 (02) :134-143
[9]  
RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
[10]   POTENTIAL MEDICATION-RELATED PROBLEMS IN NONINSTITUTIONALIZED ELDERLY [J].
SHIMP, LA ;
ASCIONE, FJ ;
GLAZER, HM ;
ATWOOD, BF .
DRUG INTELLIGENCE & CLINICAL PHARMACY, 1985, 19 (10) :766-772