BLOOMS SYNDROME COMPLICATED BY MYELODYSPLASTIC SYNDROME AND MULTIPLE NEOPLASIA

被引：9

作者：

IWAHARA, Y ^{[1
]}

ISHII, K ^{[1
]}

WATANABE, S ^{[1
]}

TAGUCHI, H ^{[1
]}

HARA, H ^{[1
]}

MIYOSHI, I ^{[1
]}

机构：

[1] KOCHI MED SCH,DEPT MED,KOCHI 783,JAPAN

来源：

INTERNAL MEDICINE | 1993年 / 32卷 / 05期

关键词：

PRELEUKEMIA; MULTIPLE CANCERS; DIABETES-MELLITUS; HEMOCHROMATOSIS;

D O I：

10.2169/internalmedicine.32.399

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

'rhe patient, a Japanese male born to a highly consanguineous family, was diagnosed as Bloom's syndrome at the age of 33 when he presented with diabetes mellitus and refractory anemia with excess blasts. Chromosome abnormalities of bone marrow cells included 5q-, -7/7q-, and unusual translocations. During the ensuing years, he developed squamous cell carcinoma of the external auditory meatus, adenocarcinoma of the colon, and squamous cell carcinoma of the tonsil. The patient died of pneumonia at the age of 38. Autopsy revealed intestinal polyposis and hemochromatosis secondary to massive blood transfusions.

引用

页码：399 / 402

页数：4

共 10 条

[1]

Bloom D., Congenital telangiectatic erythema resembling lupus erythematosus in dwarfs, Am J Dis Child, 88, (1954)

[2]

German J., Bloom's syndrome, Am J Hum Genet, 21, 1, (1969)

[3]

German J., Archibald R., Bloom D., Chromosomal breakage in a rare and probably genetically determined syndrome of man, Science, 148, (1965)

[4]

Chaganti R.S.K., Schonberg S., German J., A many fold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes, Proc Natl Acad Sci, 71, (1974)

[5]

Oono T., Arata J., Fukuma A., Miyoshi I., Bloom's syndrome with dimorphism of sister chromatid exchanges in phytohemagglutinin-stimulated lymphocytes, Arch Dermatol, 123, (1987)

[6]

German J., Takebe H., Bloom's syndrome, Clin Genet, 35, 14, (1989)

[7]

German J., Passarge E., Bloom's syndrome, Clin Genet, 35, 12, (1989)

[8]

German J., Bloom D., Passarge E., Bloom's syndrome, Clin Genet, 15, 7, (1979)

[9]

Yunis J.J., Rydell R.E., Oken M.M., Arnesen M.A., Mayer M.G., Lobell M., Refined chromosome analysis as an independent prognostic indicator in de novo myelodysplastic syndromes, Blood, 67, (1986)

[10]

Horiike S., Taniwaki M., Misawa S., Abe T., Chromosome abnormalities and karyotypic evolution in 83 patients with myelodysplastic syndrome and predictive value for prognosis, Cancer, 62, pp. 1-129, (1988)

← 1 →