CEREBRAL BLOOD-FLOW ABNORMALITIES IN ADULTS WITH INFANTILE-AUTISM

被引:62
作者
GEORGE, MS
COSTA, DC
KOURIS, K
RING, HA
ELL, PJ
机构
[1] UNIV COLL & MIDDLESEX SCH MED,INST NUCL MED,LONDON,ENGLAND
[2] INST NEUROL,DEPT CLIN NEUROL,RAYMOND WAY NEUROPSYCHIAT RES GRP,LONDON WC1N 3BG,ENGLAND
[3] MED UNIV S CAROLINA,DEPT PSYCHIAT & BEHAV SCI,CHARLESTON,SC 29425
[4] KUWAIT UNIV,DEPT NUCL MED,KUWAIT,KUWAIT
关键词
D O I
10.1097/00005053-199207000-00002
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Stuctural brain abnormalities have recently been discovered using magnetic resonance imaging in infantile autism, a neurodevelopmental disorder of unknown etiology. However, functional neuroimaging studies in autism using positron emission tomography have had conflicting results and have not explained how the known structural brain abnormalities in autism act in a functioning brain to produce autistic behavior. Using a new technology, high-resolution brain single photon emission tomography, we studied and scanned four young adults with infantile autism and four age-matched controls using the labeled ligand Tc-99m-D,L-hexamethyl-propylene amine oxime (Tc-99m-HMPAO). Total brain perfusion was significantly decreased in autism subjects (range, 58% to 72% of controls, p less-than-or-equal-to .02). In addition to the globally decreased perfusion, the autism group also had regionally decreased flow in the right lateral temporal and right, left, and midfrontal lobes compared with controls (p less-than-or-equal-to .02, Mann-Whitney t-test).
引用
收藏
页码:413 / 417
页数:5
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