REGULATION OF APOPTOSIS IN THE IMMUNE-SYSTEM

被引：322

作者：

KRAMMER, PH ^{[1
]}

BEHRMANN, I ^{[1
]}

DANIEL, P ^{[1
]}

DHEIN, J ^{[1
]}

DEBATIN, KM ^{[1
]}

机构：

[1] UNIV HEIDELBERG, CHILDRENS HOSP, W-6900 HEIDELBERG, GERMANY

来源：

CURRENT OPINION IN IMMUNOLOGY | 1994年 / 6卷 / 02期

关键词：

D O I：

10.1016/0952-7915(94)90102-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Apoptosis in T and B lymphocytes is involved in all fundamental processes in the immune system. It is a mechanism to regulate the course of an immune response and to establish immunological memory as well as central and peripheral tolerance. Apoptosis in lymphocytes is regulated by gene products that induce or block this process. Elucidating the molecular basis for sensitivity and resistance towards induction of apoptosis is the key to the understanding of the development of the immune system, basic immune reactions and the pathogenesis of autoimmune diseases, AIDS and cancer.

引用

页码：279 / 289

页数：11

共 154 条

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