CHROMOSOME INVESTIGATION IN IN-VITRO FERTILIZATION FAILURE

被引：21

作者：

MA, S ^{[1
]}

KALOUSEK, DK ^{[1
]}

YUEN, BH ^{[1
]}

GOMEL, V ^{[1
]}

KATAGIRI, S ^{[1
]}

MOON, YS ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,DEPT OBSTET & GYNECOL,DIV REPROD ENDOCRINOL & INFERTIL,VANCOUVER,BC V6H 3V5,CANADA

来源：

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | 1994年 / 11卷 / 09期

关键词：

HUMAN OOCYTES; CHROMOSOMAL ABNORMALITIES; ANEUPLOIDY; HAPLOIDY; MATERNAL AGE;

D O I：

10.1007/BF02215706

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Purpose: A chromosomal complement of 227 human oocytes was studied to provide information on the frequency and type of chromosomal abnormalities in oocytes failing in vitro fertilization. Results: Normal haploid chromosome complement was found in 54.6%; chromosomal abnormalities consisting of diploid sets were identified in 16.7% and aneuploidy was observed in 26%. Premature condensation of sperm chromosomes of the G1-phase was observed in 22.9% oocytes. Male infertility was correlated with an increase in the rate of aneuploidy when compared with tubal infertility. The rate of chromosome abnormalities for the oocytes recovered from women who had no fertilized oocytes was significantly higher compared to those with at least one oocyte fertilized. Conclusion: A high frequency of chromosome abnormalities in unfertilized oocytes suggests that natural selection against chromosome abnormalities may occur even prior to fertilization.

引用

页码：445 / 451

页数：7

共 22 条

[1]

Boue J.G., Boue A., Increased frequency of chromosome anomalies in abortion after induced ovulation, Lancet, 1, pp. 679-680, (1973)

[2]

Michelmann H.W., Mettler L., Cytogenetic investigation on human oocytes and early human embryonic stages, Fertil Steril, 43, pp. 320-322, (1985)

[3]

Wraby H., Fredga K., Liedholm P., Chromosome analysis of human oocytes recovered from preovulatory follicles in stimulated cycles, N Engl J Med, 316, pp. 121-124, (1987)

[4]

Spielmann H., Kruger C., Stauber M., Vogel R., Abnormal chromosome behavior in human oocytes which remained unfertilized during human in vitro fertilization, J In-Vitro Fert Embryo Transfer, 2, pp. 138-142, (1985)

[5]

Bongso A., Chye N.S., Ratnam S., Sathananthan H., Wong P.C., Chromosome anomalies in human oocytes failing to fertilize after insemination in vitro, Hum Reprod, 3, pp. 645-649, (1988)

[6]

Ma S., Kalousek D.K., Zouves C., Ho Yuen B., Gomel V., Moon Y.S., Chromosome analysis of human oocytes failing to fertilize in vitro, Fertil Steril, 51, pp. 992-997, (1989)

[7]

Moon Y.S., Yuen H.B., Pride S.M., Rowe T.C., Poland B.J., McComb P.F., Gomel V., A preliminary report on the establishment of pregnancies in an in vitro fertilization (IVF) program at the University of British Columbia (UBC), Gamete Res, 11, pp. 289-296, (1985)

[8]

Tarkowski A.K., An air-drying method for chromosome preparations from mouse eggs, Cytogenetics, 4, pp. 394-4000, (1966)

[9]

Benet J., Genesca A., Navarro J., Egozue J., Templado C., G-banding of human sperm chromosomes, Hum Genet, 73, pp. 181-182, (1986)

[10]

Martin R.H., Mahadevan M.M., Taylor P.J., Hildebrand K., Long-Simpson L., Peterson D., Yamamoto J., Fleetham J., Chromosomal analysis of unfertilized human oocytes, J Reprod Fertil, 78, pp. 673-678, (1986)

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