ARAGUSTEROL-A - A POTENT ANTITUMOR MARINE STEROID FROM THE OKINAWAN SPONGE OF THE GENUS, XESTOSPONGIA

被引：53

作者：

IGUCHI, K

FUJITA, M

NAGAOKA, H

MITOME, H

YAMADA, Y

机构：

[1] Tokyo College of Pharmacy, Horinouchi, Hachioji, Tokyo

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 39期

关键词：

D O I：

10.1016/S0040-4039(00)73731-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aragusterol A, a new marine steroid possessing potent antitumor activity, was isolated from the Okinawan sponge of the genus Xestospongia and its structure was determined by spectroscopic analysis and chemical evidence. The compound strongly inhibited the cell proliferation of KB, HeLaS3, P388 and LoVo cells in vitro, and also showed potent in vivo antitumor activity toward P388 in mice and L1210 in mice.

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页码：6277 / 6280

页数：4

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