ON THE CELLULAR-LOCALIZATION AND DISTRIBUTION OF CARBONIC-ANHYDRASE-II IMMUNOREACTIVITY IN THE RAT-BRAIN

被引：34

作者：

AGNATI, LF

TINNER, B

STAINES, WA

VAANANEN, K

FUXE, K

机构：

[1] KAROLINSKA INST,DEPT NEUROSCI,S-17177 STOCKHOLM,SWEDEN

[2] UNIV MODENA,DEPT HUMAN PHYSIOL,I-41100 MODENA,ITALY

[3] UNIV OULU,DEPT ANAT,OULU,FINLAND

[4] UNIV OTTAWA,DEPT ANAT & NEUROBIOL,OTTAWA,ON,CANADA

来源：

BRAIN RESEARCH | 1995年 / 676卷 / 01期

关键词：

OLIGODENDROGLIA; ASTROGLIA; CO2; BRAIN; CARBONIC ANHYDRASE II;

D O I：

10.1016/0006-8993(95)00026-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Evidence is provided that carbonic anhydrase-II is localized in the central nervous system to wide spread systems of oligodendrocytes and restricted astroglia populations, involving both fiber bundles and neuropil. It is suggested that CO, formed in activated axons may, via carbonic anhydrase-II, give rise to protons controlling the excitability of surrounding neuropil. Thus, CO2 may represent an important, highly diffusible, signal in brain, involved in the tonic control of neuronal activity.

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页码：10 / 24

页数：15

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