ANTIGENIC ANALYSIS OF CURRENT WILD-TYPE AND VACCINE STRAINS OF MEASLES-VIRUS

被引：92

作者：

TAMIN, A ^{[1
]}

ROTA, PA ^{[1
]}

WANG, ZD ^{[1
]}

HEATH, JL ^{[1
]}

ANDERSON, LJ ^{[1
]}

BELLINI, WJ ^{[1
]}

机构：

[1] CTR DIS CONTROL,NATL CTR INFECT DIS,REVB,DIV VIRAL & RICKETTSIAL DIS,MEASLES SECT,ATLANTA,GA 30333

来源：

JOURNAL OF INFECTIOUS DISEASES | 1994年 / 170卷 / 04期

关键词：

D O I：

10.1093/infdis/170.4.795

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The antigenic properties of vaccine and wild type strains of measles virus were compared. Serum specimens from vaccinated persons, persons infected during the prevaccine era, or mice experimentally vaccinated with the hemagglutinin (H) protein from vaccine virus neutralized vaccine virus and a wild type measles virus from 1989 equally well. In contrast, serum specimens from patients with recent measles virus infection and mice experimentally vaccinated with the H protein from the wild type virus from 1989 neutralized wild type virus with titers 4-8 times higher than those to vaccine virus. Several H protein-specific monoclonal antibodies could differentially recognize vaccine or wild type virus. These data show that the H proteins of the recent wild type viruses contain both conserved and new or modified antigenic determinants and are consistent with previous studies that described genetic drift in the H proteins of recent wild type viruses.

引用

页码：795 / 801

页数：7

共 39 条

[1] ROLE OF VIRUS-STRAIN IN CONVENTIONAL AND ENHANCED MEASLES PLAQUE NEUTRALIZATION TEST [J].

ALBRECHT, P ;

HERRMANN, K ;

BURNS, GR .

JOURNAL OF VIROLOGICAL METHODS, 1981, 3 (05) :251-260

[2] NUCLEOTIDE-SEQUENCE OF THE GENES ENCODING THE MATRIX PROTEIN OF 2 WILD-TYPE MEASLES-VIRUS STRAINS [J].

BACZKO, K ;

BRINCKMANN, U ;

PARDOWITZ, I ;

RIMA, BK ;

TERMEULEN, V .

JOURNAL OF GENERAL VIROLOGY, 1991, 72 :2279-2282

[3] CONSTANT AND VARIABLE REGIONS OF MEASLES-VIRUS PROTEINS ENCODED BY THE NUCLEOCAPSID AND PHOSPHOPROTEIN GENES DERIVED FROM LYTIC AND PERSISTENT VIRUSES [J].

BACZKO, K ;

PARDOWITZ, I ;

RIMA, BK ;

TERMEULEN, V .

VIROLOGY, 1992, 190 (01) :469-474

[4] PURIFICATION OF MEASLES-VIRUS WITH PRESERVATION OF INFECTIVITY AND ANTIGENICITY [J].

BELLINI, WJ ;

TRUDGETT, A ;

MCFARLIN, DE .

JOURNAL OF GENERAL VIROLOGY, 1979, 43 (JUN) :633-639

[5]

BLACK RA, 1992, J GEN VIROL, V74, P143

[6] ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE [J].

CHIRGWIN, JM ;

PRZYBYLA, AE ;

MACDONALD, RJ ;

RUTTER, WJ .

BIOCHEMISTRY, 1979, 18 (24) :5294-5299

[7] PROTECTION OF MICE FROM FATAL MEASLES ENCEPHALITIS BY VACCINATION WITH VACCINIA VIRUS RECOMBINANTS ENCODING EITHER THE HEMAGGLUTININ OR THE FUSION PROTEIN [J].

DRILLIEN, R ;

SPEHNER, D ;

KIRN, A ;

GIRAUDON, P ;

BUCKLAND, R ;

WILD, F ;

LECOCQ, JP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (04) :1252-1256

[8] EVALUATION OF MONOCLONAL ANTIBODY-BASED CAPTURE ENZYME IMMUNOASSAYS FOR DETECTION OF SPECIFIC ANTIBODIES TO MEASLES-VIRUS [J].

ERDMAN, DD ;

ANDERSON, LJ ;

ADAMS, DR ;

STEWART, JA ;

MARKOWITZ, LE ;

BELLINI, WJ .

JOURNAL OF CLINICAL MICROBIOLOGY, 1991, 29 (07) :1466-1471

[9] NEOMYCIN RESISTANCE AS A DOMINANT SELECTABLE MARKER FOR SELECTION AND ISOLATION OF VACCINIA VIRUS RECOMBINANTS [J].

FRANKE, CA ;

RICE, CM ;

STRAUSS, JH ;

HRUBY, DE .

MOLECULAR AND CELLULAR BIOLOGY, 1985, 5 (08) :1918-1924

[10] CORRELATION BETWEEN EPITOPES ON HEMAGGLUTININ OF MEASLES-VIRUS AND BIOLOGICAL-ACTIVITIES - PASSIVE PROTECTION BY MONOCLONAL-ANTIBODIES IS RELATED TO THEIR HEMAGGLUTINATION INHIBITING ACTIVITY [J].

GIRAUDON, P ;

WILD, TF .

VIROLOGY, 1985, 144 (01) :46-58

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