WHY DO PROTEIN ARCHITECTURES HAVE BOLTZMANN-LIKE STATISTICS

被引：168

作者：

FINKELSTEIN, AV

BADRETDINOV, AY

GUTIN, AM

机构：

[1] Institute of Protein Research, Russian Academy of Sciences, Moscow, 142-292, Pushchino

[2] Department of Chemistry, Harvard University, Cambridge, Massachusetts

来源：

PROTEINS-STRUCTURE FUNCTION AND GENETICS | 1995年 / 23卷 / 02期

关键词：

PROTEIN STRUCTURE; STABILITY; STATISTICS; CONFORMATIONAL TEMPERATURE OF PROTEIN STATISTICS; MELTING TEMPERATURE; RANDOM SEQUENCES;

D O I：

10.1002/prot.340230204

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A theoretical study has shown that the occurrence of various structural elements in stable folds of random copolymers is exponentially dependent on the own energy of the element. A similar occurrence-on-energy dependence is observed in globular proteins(1) from the level of amino acid conformations to the level of overall architectures. Thus, the structural features stabilized by many random sequences are typical of globular proteins while the features rarely observed in proteins are those which are stabilized by only a minor part of the random sequences. (C) 1995 Wiley-Liss, Inc.

引用

页码：142 / 150

页数：9

共 37 条

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