DAILY SUSCEPTIBILITY RHYTHM TO MORPHINE ANALGESIA

被引：36

作者：

MORRIS, RW

LUTSCH, EF

机构：

[1] College of Pharmacy, University of Illinois, Chicago, Illinois

[2] Department of Biological Sciences, Northeastern Illinois State College, Chicago, Illinois

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 03期

关键词：

Light; dark phases—morphine analgesia; Lunar phases—morphine analgesia; Morphine analgesia—daily response rhythm; Susceptibility patterns; mice—morphine analgesia;

D O I：

10.1002/jps.2600580324

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Mice exhibit a daily susceptibility to morphine‐induced analgesia, that is, maximum sensitivity (crest) at 2100–2400 hr. in the dark phase and a minimum (trough) at 1500 (light phase). Shifts in the crest and/or trough of from 3 to 6 hr. were evident on three experimental dates; however, the crests and troughs always remained within their respective light phases. A discussion is presented on the interrelationships among the rhythms for catecholamine metabolism, motor activity, and susceptibility to stimulant and depressant drugs, particularly morphine. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：374 / &

共 29 条

[1]

AXELROD J, 1965, J BIOL CHEM, V240, P949

[2] EXPERIMENTAL OBSERVATIONS ON HAFFNER METHOD FOR TESTING ANALGESIC DRUGS [J].