NEUROTOXICITY OF SODIUM DIETHYLDITHIOCARBAMATE IN RABBIT

被引：21

作者：

EDINGTON, N

HOWELL, JM

机构：

[1] Department of Veterinary Pathology, University of Liverpool, Liverpool

[2] Department of Pathology, The Royal Veterinary College, Camden Town London

来源：

ACTA NEUROPATHOLOGICA | 1969年 / 12卷 / 04期

关键词：

Axonal Swelling; Degenerative Changes; Neurone Degeneration; Sodium Diethyldithiocarbamate Intoxication;

D O I：

10.1007/BF00809130

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The development of the lesion caused by NDDC in the CNS of adult rabbits was studied by killing rabbits receiving NDDC at 6 week intervals. The first changes were seen at 6 weeks in the accessory cuneate nucleus and in Clarke's column. 12 weeks later degenerative changes were seen in the spinocerebellar tracts in the cerebellum, medulla. The rabbits killed after 24 weeks showed severe nerve fibre degeneration in the peripheral white matter of the spinal cord. Changes in peripheral nerves were minimal. This neuraxonal degeneration" is discussed in relation to similar changes seen in human and animal neuropathology. © 1969 Springer-Verlag."

引用

页码：339 / &

共 30 条

[1] A HISTOCHEMICAL METHOD FOR THE SIMULTANEOUS DEMONSTRATION OF NORMAL AND DEGENERATING MYELIN [J].