EFFECT OF BETA-ADRENERGIC BLOCKING-DRUGS ON THE INTRINSIC BEATING RATE OF CULTURED RAT MYOCYTES

被引：19

作者：

HIGGINS, TJC

ALLSOPP, D

BAILEY, PJ

机构：

[1] Biochemistry Department, I.C.I. Limited, Pharmaceuticals Division, Cheshire SK10 4TG, Alderley Park

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 1979年 / 11卷 / 01期

关键词：

Atenolol; Beating rate; Myocyte cultures; Pacemaker; Propranolol; β-Receptor;

D O I：

10.1016/0022-2828(79)90455-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cultured myocytes from neonate rats were subject to increasing doses of dl-, d- or l-propranolol or dl-atenolol, and the intrinsic heart rates were measured. Both propranolol isomers and racemate stopped beating activity at very high concentrations (10-3 m) while atenolol did not. The results are interpreted to indicate that constant β-adrenoceptor stimulation is not an obligatory requirement for maintenance of spontaneous beating in this system as has been suggested. © 1979.

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页码：101 / 107

页数：7

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