HYPER-PROLACTINEMIA AND HYPOGONADISM IN MEN - RESPONSE TO EXOGENOUS GONADOTROPINS

被引:19
作者
LUBOSHITZKY, R
ROSEN, E
TRESTIAN, S
SPITZ, IM
机构
[1] SHAARE ZEDEK MED CTR,DEPT ENDOCRINOL & METAB,JERUSALEM,ISRAEL
[2] RAMBAM UNIV HOSP,INST ENDOCRINE,HAIFA,ISRAEL
关键词
D O I
10.1111/j.1365-2265.1979.tb03067.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Three male patients with pituitary tumours and marked hyperprolactinaemia were investigated. Their prolactin (PRL) levels ranged from 210 to 2500 ng/ml. The subjects had clinical and laboratory characteristics of hypogonadotrophic hypo‐gonadism. All were treated with human chorionic gonadotrophin (HCG) and in one subject human menopausal gonadotrophin (HMG) was given in addition. In all three patients, despite the persistence of hyperprolactinaemia, serum testosterone had risen to normal levels within 4–17 days after starting HCG. Despite the normal testosterone level, impotence persisted in two patients and the third had persistently decreased libido. The hypogonadism in these patients may be related to an absolute reduction in gonadotroph number secondary to destruction by tumour mass. Alternatively, hyperprolactinaemia may inhibit the synthesis or release of the gonado‐trophins or LHRH. Despite hyperprolactinaemia, pharmacological doses of HCG induced testosterone secretion in all these three subjects. Copyright © 1979, Wiley Blackwell. All rights reserved
引用
收藏
页码:217 / 223
页数:7
相关论文
共 30 条
[1]   EFFECT OF SULPIRIDE-INDUCED HYPERPROLACTINEMIA ON SERUM TESTOSTERONE RESPONSE TO HCG IN NORMAL MEN [J].
AMBROSI, B ;
TRAVAGLINI, P ;
BECKPECCOZ, P ;
BARA, R ;
ELLI, R ;
PARACCHI, A ;
FAGLIA, G .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1976, 43 (03) :700-703
[2]   HYPOGONADISM, GALACTORRHEA AND HYPER-PROLACTINEMIA - EVALUATION OF PITUITARY GONADOTROPINS RESERVE BEFORE AND UNDER BROMOCRIPTINE [J].
ASFOUR, M ;
LHERMITE, M ;
HEDOUINQUINCAMPOIX, M ;
FOSSATI, P .
ACTA ENDOCRINOLOGICA, 1977, 84 (04) :738-749
[3]   SPECIFIC BINDING OF PROLACTIN TO SEMINAL-VESICLE, PROSTATE AND TESTICULAR HOMOGENATES OF IMMATURE, MATURE AND AGED RATS [J].
BARKEY, RJ ;
SHANI, J ;
AMIT, T ;
BARZILAI, D .
JOURNAL OF ENDOCRINOLOGY, 1977, 74 (02) :163-173
[4]   EFFECTS OF PROLACTIN ON SPERMATOGENESIS IN HYPOPHYSECTOMIZED MICE [J].
BARTKE, A .
JOURNAL OF ENDOCRINOLOGY, 1971, 49 (02) :311-&
[5]  
BARTKE A, 1976, PROGR REPRODUCTIVE B, V1, P136
[6]  
BESSER GM, 1977, ACTA ENDOCRINOL S212, V85, P518
[7]   HYPOTHALAMIC-PITUITARY FUNCTION IN DIVERSE HYPERPROLACTINEMIC STATES [J].
BOYAR, RM ;
KAPEN, S ;
FINKELSTEIN, JW ;
PERLOW, M ;
SASSIN, JF ;
FUKUSHIMA, DK ;
WEITZMAN, ED ;
HELLMAN, L .
JOURNAL OF CLINICAL INVESTIGATION, 1974, 53 (06) :1588-1598
[8]   PROLACTIN-SECRETING TUMORS AND HYPOGONADISM IN 22 MEN [J].
CARTER, JN ;
TYSON, JE ;
TOLIS, G ;
VANVLIET, S ;
FAIMAN, C ;
FRIESEN, HG .
NEW ENGLAND JOURNAL OF MEDICINE, 1978, 299 (16) :847-852
[9]   PROLACTIN STUDIES IN FUNCTIONLESS PITUITARY TUMORS [J].
CHILD, DF ;
NADER, S ;
MASHITER, K ;
KJELD, M ;
BANKS, L ;
FRASER, TR .
BRITISH MEDICAL JOURNAL, 1975, 1 (5958) :604-606
[10]   HYPOGONADISM INDUCED BY A TRANSPLANTABLE, PROLACTIN-PRODUCING TUMOR IN MALE RATS - HORMONAL AND MORPHOLOGICAL STUDIES [J].
FANG, VS ;
REFETOFF, S ;
ROSENFIELD, RL .
ENDOCRINOLOGY, 1974, 95 (04) :991-998