ANTIPHOSPHOLIPID ANTIBODY ISOTYPES IN NORMAL HUMAN SERA

被引：10

作者：

CHENG, HM ^{[1
]}

WONG, KK ^{[1
]}

机构：

[1] UNIV MALAYA,FAC MED,DEPT OBSTET & GYNAECOL,KUALA LUMPUR 2211,MALAYSIA

来源：

IMMUNOLOGY LETTERS | 1990年 / 23卷 / 03期

关键词：

Anti-phospholipid; Co-factor; ELISA; Isotype;

D O I：

10.1016/0165-2478(90)90189-W

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Heat-sensitive serum masking cofactor(s) of anti-phospholipid antibody (aPL) in normal human sera (NHS) are specifically inactivated at 56°C. The degree of binding in ELISA by unmasked aPL in NHS was equivalent to that in non-heated, aPL-reactive autoimmune SLE sera. Previously "negative" SLE sera also reacted equally strongly in the aPL ELISA when similarly heat-inactivated. Isotype studies by ELISA of the heat-potentiated aPL in 36 NHS revealed the presence of specific IgG ( 34 36), IgM ( 11 36) and IgA ( 24 36) aPL antibodies. 11 36 (31%) NHS had all three aPL isotypes while 13 36 (36%) had both IgG and IgA antibodies to phospholipid. © 1990.

引用

页码：183 / 186

页数：4

共 20 条

[1] CHANGES IN MEMBRANE PHOSPHOLIPID DISTRIBUTION DURING PLATELET ACTIVATION [J].

BEVERS, EM ;

COMFURIUS, P ;

ZWAAL, RFA .

BIOCHIMICA ET BIOPHYSICA ACTA, 1983, 736 (01) :57-66

[2] ANTIPHOSPHOLIPID ANTIBODY SYNDROME - A REVIEW [J].

BINGLEY, PJ ;

HOFFBRAND, BI .

JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, 1987, 80 (07) :445-448

[3]

CARROLL P, 1985, J IMMUNOL, V135, P1086

[4]

CHENG HM, 1988, J IMMUNOL METHODS, V109, P253

[5] HEAT-LABILE SERUM INHIBITOR OF ANTI-PHOSPHOLIPID ANTIBODY-BINDING IN ELISA [J].

CHENG, HM ;

PHUAH, EB .

IMMUNOLOGY LETTERS, 1989, 22 (04) :263-266

[6]

CHENG HM, 1988, AM J OBSTET GYNECOL, V158, P441

[7]

CRONIN ME, 1988, J RHEUMATOL, V15, P795

[8]

DELEZE M, 1988, J RHEUMATOL, V15, P611

[9]

DERKSEN RHW, 1987, LANCET, V1, P222

[10] IGM GAMMOPATHY AND THE LUPUS ANTICOAGULANT SYNDROME IN HABITUAL ABORTERS [J].

GLEICHER, N ;

FRIBERG, J .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1985, 253 (22) :3278-3281

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