BIOLOGICALLY BASED QSARS - STUDY OF CARDANOL DERIVATIVES ON INTERACTION WITH SACCHAROMYCES-CEREVISIAE

被引：11

作者：

DEMORAIS, SM ^{[1
]}

BEEZER, AE ^{[1
]}

ASHBY, LJ ^{[1
]}

BOLTON, R ^{[1
]}

机构：

[1] UNIV LONDON ROYAL HOLLOWAY & BEDFORD NEW COLL,DEPT CHEM,EGHAM TW20 0EX,SURREY,ENGLAND

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1990年 / 66卷 / 1-3期

关键词：

QSAR; LFER; MICROCALORIMETRY; CARDANOL DERIVATIVE;

D O I：

10.1016/0378-5173(90)90390-P

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Derivatives of the cashew nut component shell liquid have been examined for antifungal activity by microcalorimetry. The dose/ response data are shown to be useful in establishing a Linear Free Energy Relationship. The data are the first to show that such a biologically based quantitative structure-activity relationship (QSAR) can be applied to antifungals - and to derivatives of natural products.

引用

页码：107 / 110

页数：4

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