DIFFERENT SEQUENCE ENVIRONMENTS OF CYSTEINES AND HALF CYSTINES IN PROTEINS APPLICATION TO PREDICT DISULFIDE FORMING RESIDUES

被引：58

作者：

FISER, A ^{[1
]}

CSERZO, M ^{[1
]}

TUDOS, E ^{[1
]}

SIMON, I ^{[1
]}

机构：

[1] HUNGARIAN ACAD SCI,BIOL RES CTR,INST ENZYMOL,POB 7,H-1518 BUDAPEST,HUNGARY

来源：

FEBS LETTERS | 1992年 / 302卷 / 02期

关键词：

PREDICTION; FREE CYSTEINE; HALF CYSTINE; SEQUENTIAL ENVIRONMENT;

D O I：

10.1016/0014-5793(92)80419-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein sequences are often derived by translating genetic information, rather than by classical protein sequencing. At the DNA level cysteines and half cystines are indistinguishable. Here we show that the sequential environments of 'free' cysteine and half cystine are different. A possible origin of this difference is discussed and a simple method to predict cysteines and half cystines from the amino acid sequence is also presented.

引用

页码：117 / 120

页数：4

共 11 条

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