ANDROGEN RECEPTOR ABNORMALITY IN X-LINKED SPINAL AND BULBAR MUSCULAR-ATROPHY

被引：27

作者：

MATSUURA, T ^{[1
]}

DEMURA, T ^{[1
]}

AIMOTO, Y ^{[1
]}

MIZUNO, T ^{[1
]}

MORIWAKA, F ^{[1
]}

TASHIRO, K ^{[1
]}

机构：

[1] HOKKAIDO UNIV,SCH MED,DEPT UROL,SAPPORO,HOKKAIDO 060,JAPAN

来源：

NEUROLOGY | 1992年 / 42卷 / 09期

关键词：

D O I：

10.1212/WNL.42.9.1724

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

X-linked spinal and bulbar muscular atrophy (SBMA) is usually associated with feminization and hypogonadism. We were unable to find androgen receptor (AR) in the scrotal skin of three patients with SBMA, and propose that AR abnormality is the cause of the disease.

引用

页码：1724 / 1726

页数：3

共 26 条

[1] CULTURED HUMAN-SKIN FIBROBLASTS - A MODEL FOR THE STUDY OF ANDROGEN ACTION [J].

BROWN, TR ;

MIGEON, CJ .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 1981, 36 (01) :3-22

[2] MOLECULAR-CLONING OF HUMAN AND RAT COMPLEMENTARY-DNA ENCODING ANDROGEN RECEPTORS [J].

CHANG, CS ;

KOKONTIS, J ;

LIAO, SS .

SCIENCE, 1988, 240 (4850) :324-326

[3]

DEMURA T, 1989, J STEROID BIOCHEM, V33, P845

[4]

DEMURA T, 1988, AM J CLIN ONCOL-CANC, V11, P523

[5]

FISHBECK KH, 1986, NEUROLOGY, V36, P1595

[6] TESTICULAR FEMINIZATION ASSOCIATED WITH A THERMOLABILE ANDROGEN RECEPTOR IN CULTURED HUMAN-FIBROBLASTS [J].

GRIFFIN, JE .

JOURNAL OF CLINICAL INVESTIGATION, 1979, 64 (06) :1624-1631

[7] SYNDROMES OF ANDROGEN RESISTANCE [J].

GRIFFIN, JE ;

WILSON, JD .

NEW ENGLAND JOURNAL OF MEDICINE, 1980, 302 (04) :198-209

[8] USE OF AVIDIN-BIOTIN-PEROXIDASE COMPLEX (ABC) IN IMMUNOPEROXIDASE TECHNIQUES - A COMPARISON BETWEEN ABC AND UNLABELED ANTIBODY (PAP) PROCEDURES [J].

HSU, SM ;

RAINE, L ;

FANGER, H .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1981, 29 (04) :577-580

[9] X-LINKED DOMINANT CHARCOT-MARIE-TOOTH NEUROPATHY WITH 15 CASES IN A FAMILY GENETIC-LINKAGE STUDY [J].

IONASESCU, VV ;

BURNS, TL ;

SEARBY, C ;

IONASESCU, R .

MUSCLE & NERVE, 1988, 11 (11) :1154-1156

[10] ANDROGENS REGULATE THE DENDRITIC LENGTH OF MAMMALIAN MOTONEURONS IN ADULTHOOD [J].

KURZ, EM ;

SENGELAUB, DR ;

ARNOLD, AP .

SCIENCE, 1986, 232 (4748) :395-398

← 1 2 3 →