EXTERNAL K+ INCREASES NA+ CONDUCTANCE OF THE HYPERPOLARIZATION-ACTIVATED CURRENT IN RABBIT CARDIAC-PACEMAKER CELLS

被引：21

作者：

FRACE, AM ^{[1
]}

MARUOKA, F ^{[1
]}

NOMA, A ^{[1
]}

机构：

[1] KYUSHU UNIV,FAC MED,DEPT PHYSIOL,FUKUOKA 812,JAPAN

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 1992年 / 421卷 / 01期

关键词：

CALCIUM ACTIVATED K+ CHANNELS; ADENOSINE TRIPHOSPHATE; PULMONARY ARTERY; HYPOXIC VASOCONSTRICTION;

D O I：

10.1007/BF00374739

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

We have observed a novel class of calcium-activated potassium channel which is activated by physiological levels of intracellular ATP. These K(ca,ATP) channels are found on smooth muscle cells isolated from the pulmonary artery. Since their activation by ATP is Mg2+ dependent and is poorly evoked by non- or slowly-hydrolyzed ATP analogues, we conclude that it involves phosphorylation. We suggest that in hypoxia a reduction of intracellular ATP may reduce K(ca,ATP) channel activity and thereby tend to depolarize the cells. This effect would increase Ca2+ entry through voltage-activated Ca2+ channels and contribute to vasoconstriction.

引用

页码：94 / 96

页数：3

共 14 条

[1] BERNE RM, 1979, HDB PHYSL 2, V1, P387
[2] PROTEIN-KINASE ACTIVITY CLOSELY ASSOCIATED WITH A RECONSTITUTED CALCIUM-ACTIVATED POTASSIUM CHANNEL
CHUNG, SK
REINHART, PH
MARTIN, BL
BRAUTIGAN, D
LEVITAN, IB
[J]. SCIENCE, 1991, 253 (5019) : 560 - 562
[3] HYPOXIC DILATION OF CORONARY-ARTERIES IS MEDIATED BY ATP-SENSITIVE POTASSIUM CHANNELS
DAUT, J
MAIERRUDOLPH, W
VONBECKERATH, N
MEHRKE, G
GUNTHER, K
GOEDELMEINEN, L
[J]. SCIENCE, 1990, 247 (4948) : 1341 - 1344
[4] MODULATION OF SINGLE CA-2+-DEPENDENT K+-CHANNEL ACTIVITY BY PROTEIN-PHOSPHORYLATION
EWALD, DA
WILLIAMS, A
LEVITAN, IB
[J]. NATURE, 1985, 315 (6019) : 503 - 506
[5] IMPROVED PATCH-CLAMP TECHNIQUES FOR HIGH-RESOLUTION CURRENT RECORDING FROM CELLS AND CELL-FREE MEMBRANE PATCHES
HAMILL, OP
MARTY, A
NEHER, E
SAKMANN, B
SIGWORTH, FJ
[J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1981, 391 (02): : 85 - 100
[6] DUAL EFFECTS OF DIAZOXIDE ON ATP-K+ CURRENTS RECORDED FROM AN INSULIN-SECRETING CELL-LINE
KOZLOWSKI, RZ
HALES, CN
ASHFORD, MLJ
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1989, 97 (04) : 1039 - 1050
[7] HYPOXIC PULMONARY VASOCONSTRICTION - ROLE OF PERIVASCULAR TISSUE
LLOYD, TC
[J]. JOURNAL OF APPLIED PHYSIOLOGY, 1968, 25 (05) : 560 - &
[8] EFFECTS OF HYPOXIA UPON CONTRACTIONS EVOKED IN ISOLATED RABBIT PULMONARY-ARTERY BY POTASSIUM AND NORADRENALINE
MARRIOTT, JF
MARSHALL, JM
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1990, 422 : 15 - 28
[9] MARSHALL C, 1988, P SOC EXP BIOL MED, V187, P282
[10] MENTZER RM, 1975, AM J PHYSIOL, V229, P1625

← 1 2 →