ACTIVATION OF PROTEIN-KINASE-C IS NOT REQUIRED FOR GLYCERALDEHYDE-STIMULATED INSULIN-SECRETION FROM RAT ISLETS

被引：16

作者：

PERSAUD, SJ

JONES, PM

HOWELL, SL

机构：

[1] Biomedical Sciences Division, King's College London, London

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1095卷 / 02期

关键词：

ISLETS OF LANGERHANS; GLYCERALDEHYDE; PROTEIN KINASE-C; PHORBOL ESTER; TRANSLOCATION; INSULIN SECRETION;

D O I：

10.1016/0167-4889(91)90082-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glyceraldehyde-induced insulin release from rat islets of Langerhans was not affected following down-regulation of protein kinase C (PKC) by prolonged exposure to the tumour-promoting phorbol ester, 4-beta-phorbol myristate acetate (PMA). Glyceraldehyde did not cause translocation of islet PKC under conditions in which PMA stimulated redistribution of enzyme activity. These results indicate that activation of PKC is not required for glyceraldehyde stimulation of insulin secretion from normal rat islets.

引用

收藏

页码：183 / 185

页数：3

相关论文

共 24 条

[1] INTERRELATIONSHIP OF ISLET METABOLISM, ADENOSINE-TRIPHOSPHATE CONTENT AND INSULIN RELEASE [J].

ASHCROFT, SJ ;

WEERASINGHE, LC ;

RANDLE, PJ .

BIOCHEMICAL JOURNAL, 1973, 132 (02) :223-231

[2] ROLE OF INTRACELLULAR MEDIATORS IN GLUCAGON-SECRETION - STUDIES USING INTACT AND ELECTRICALLY PERMEABILIZED RAT ISLETS OF LANGERHANS [J].

BJAALAND, T ;

JONES, PM ;

HOWELL, SL .

JOURNAL OF MOLECULAR ENDOCRINOLOGY, 1988, 1 (03) :171-178

[3] COMPARISON OF EFFECTS OF PHORBOL ESTERS AND GLUCOSE ON PROTEIN KINASE-C ACTIVATION AND INSULIN-SECRETION IN PANCREATIC-ISLETS [J].

EASOM, RA ;

HUGHES, JH ;

LANDT, M ;

WOLF, BA ;

TURK, J ;

MCDANIEL, ML .

BIOCHEMICAL JOURNAL, 1989, 264 (01) :27-33

[4] GLUCOSE-INDUCED TRANSLOCATION OF PROTEIN-KINASE-C IN RAT PANCREATIC-ISLETS [J].

GANESAN, S ;

CALLE, R ;

ZAWALICH, K ;

SMALLWOOD, JI ;

ZAWALICH, WS ;

RASMUSSEN, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (24) :9893-9897

[5]

GEY GEORGE 0., 1936, AMER JOUR CANCER, V27, P45

[6] PANCREATIC BETA-CELL RECOGNITION OF INSULIN SECRETAGOGUES - COMPARISONS OF GLUCOSE WITH GLYCERALDEHYDE ISOMERS AND DIHYDROXYACETONE [J].

HELLMAN, B ;

IDAHL, LA ;

LERNMARK, A ;

SEHLIN, J ;

TALJEDAL, IB .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1974, 162 (02) :448-457

[7]

HENQUIN JC, 1989, DIABETOLOGIA, V32, pA496

[8] A REASSESSMENT OF THE ROLE OF PROTEIN-KINASE-C IN GLUCOSE-STIMULATED INSULIN-SECRETION [J].

HII, CST ;

JONES, PM ;

PERSAUD, SJ ;

HOWELL, SL .

BIOCHEMICAL JOURNAL, 1987, 246 (02) :489-493

[9] LOCALIZATION OF BETA-II SUBSPECIES OF PROTEIN KINASE-C IN BETA-CELLS [J].

ITO, A ;

SAITO, N ;

TANIGUCHI, H ;

CHIBA, T ;

KIKKAWA, U ;

SAITOH, Y ;

TANAKA, C .

DIABETES, 1989, 38 (08) :1005-1011

[10] PROTEIN-PHOSPHORYLATION IN ELECTRICALLY PERMEABILIZED ISLETS OF LANGERHANS - EFFECTS OF CA-2+, CYCLIC-AMP, A PHORBOL ESTER AND NORADRENALINE [J].

JONES, PM ;

SALMON, DMW ;

HOWELL, SL .

BIOCHEMICAL JOURNAL, 1988, 254 (02) :397-403