SIMPLE CHIRAL LIQUID-CHROMATOGRAPHIC ENANTIOSEPARATION OF SOME RACEMIC ANTIEPILEPTIC DRUGS

被引：24

作者：

ABOULENEIN, HY ^{[1
]}

SERIGNESE, V ^{[1
]}

BOJARSKI, J ^{[1
]}

机构：

[1] NICHOLAS COPERNICUS MED ACAD,DEPT ORGAN CHEM,PL-30048 KRAKOW,POLAND

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1993年 / 16卷 / 13期

关键词：

D O I：

10.1080/10826079308019609

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Cellulose tris (4-methylbenzoate) known as Chiralcel OJ chiral stationary phase (CSP) has been successfully used for the enantioseparation of three clinically used antiepileptic drugs namely, mephobarbital, mephenytoin and benzonal. The chemical structure-chiral recognition mechanisms related to the enantiomeric elution order of these drugs are discussed.

引用

页码：2741 / 2749

页数：9

共 30 条

[1] STRUCTURAL FACTORS AFFECTING CHIRAL RECOGNITION AND SEPARATION ON CELLULOSE BASED CHIRAL STATIONARY PHASES [J].

ABOULENEIN, HY ;

ISLAM, MR .

JOURNAL OF LIQUID CHROMATOGRAPHY, 1990, 13 (03) :485-492

[2] ISOCRATIC HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC RESOLUTION OF GLUTETHIMIDE ENANTIOMERS AND THEIR 4-HYDROXYGLUTETHIMIDE METABOLITES USING CELLULOSE TRIBENZOATE CHIRAL STATIONARY PHASE [J].

ABOULENEIN, HY ;

ISLAM, MR .

JOURNAL OF CHROMATOGRAPHIC SCIENCE, 1990, 28 (06) :307-310

[3]

ABOULENEIN HY, 1992, ANAL LETT, V35, P231

[4] DIRECT LIQUID-CHROMATOGRAPHIC SEPARATION OF ENANTIOMERS ON IMMOBILIZED PROTEIN STATIONARY PHASES .6. OPTICAL RESOLUTION OF A SERIES OF RACEMIC BARBITURATES - STUDIES OF SUBSTITUENT AND MOBILE PHASE EFFECTS [J].

ALLENMARK, S ;

ANDERSSON, S ;

BOJARSKI, J .

JOURNAL OF CHROMATOGRAPHY, 1988, 436 (03) :479-483

[5]

ANDERSON RA, 1992, J CHROMATOGR, V591, P65

[6] SEPARATION OF DRUG STEREOISOMERS BY THE FORMATION OF BETA-CYCLODEXTRIN INCLUSION COMPLEXES [J].

ARMSTRONG, DW ;

WARD, TJ ;

ARMSTRONG, RD ;

BEESLEY, TE .

SCIENCE, 1986, 232 (4754) :1132-1135

[7] PLANAR CHROMATOGRAPHIC-SEPARATION OF ENANTIOMERS AND DIASTEREOMERS WITH CYCLODEXTRIN MOBILE PHASE ADDITIVES [J].

ARMSTRONG, DW ;

HE, FY ;

HAN, SM .

JOURNAL OF CHROMATOGRAPHY, 1988, 448 (03) :345-354

[8] CAPILLARY GAS-CHROMATOGRAPHIC SEPARATION OF ENANTIOMERS WITH STABLE DIPENTYL-ALPHA-CYCLODEXTRIN-DERIVATIZED, BETA-CYCLODEXTRIN-DERIVATIZED AND GAMMA-CYCLODEXTRIN-DERIVATIZED STATIONARY PHASES [J].

ARMSTRONG, DW ;

LI, WY ;

STALCUP, AM ;

SECOR, HV ;

IZAC, RR ;

SEEMAN, JI .

ANALYTICA CHIMICA ACTA, 1990, 234 (02) :365-380

[9] CYCLODEXTRIN CHIRAL STATIONARY PHASES FOR LIQUID-CHROMATOGRAPHIC SEPARATIONS OF DRUG STEREOISOMERS [J].

BERTHOD, A ;

JIN, HL ;

BEESLEY, TE ;

DUNCAN, JD ;

ARMSTRONG, DW .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1990, 8 (02) :123-130

[10] CHROMATOGRAPHIC RESOLUTIONS .12. RESOLUTION OF CHIRAL N-METHYLBARBITURATES AND PHENYLCYANOACETIC ACID-ESTERS ON CELLULOSE TRIACETATE [J].

BLASCHKE, G ;

MARKGRAF, H .

ARCHIV DER PHARMAZIE, 1984, 317 (05) :465-471

← 1 2 3 →