APOLIPOPROTEIN-E EPSILON-4 ALLELE FREQUENCY IN PATIENTS WITH LEWY BODY DEMENTIA, ALZHEIMERS-DISEASE AND AGE-MATCHED CONTROLS

被引：78

作者：

STCLAIR, D

NORRMAN, J

PERRY, R

YATES, C

WILCOCK, G

BROOKES, A

机构：

[1] NEWCASTLE GEN HOSP,DEPT NEUROPATHOL,NEWCASTLE TYNE NE4 6BE,ENGLAND

[2] NEWCASTLE GEN HOSP,MRC,NEUROCHEM PATHOL UNIT,NEWCASTLE TYNE NE4 6BE,ENGLAND

[3] UNIV EDINBURGH,ROYAL EDINBURGH HOSP,MRC,BRAIN METAB UNIT,EDINBURGH EH10 5HF,SCOTLAND

[4] FRENCHAY HOSP,DEPT CARE ELDERLY,BRISTOL BS16 1LE,ENGLAND

来源：

NEUROSCIENCE LETTERS | 1994年 / 176卷 / 01期

基金：

英国惠康基金;

关键词：

APOLIPOPROTEIN E; LEWY BODY DEMENTIA; ALZHEIMERS DISEASE; GENOTYPE; POLYMERASE-CHAIN REACTION;

D O I：

10.1016/0304-3940(94)90867-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Genotypes of apolipoprotein E (ApoE) were determined by polymerase-chain reaction (PCR) amplification and restriction-sizing of brain DNA from 39 cases of Lewy body dementia (LBD), 68 senile Alzheimer's disease (AD) patients and 47 neuropathologically validated non-demented controls. There was a 3-fold increase in the epsilon 4 allele frequency in both LBD and AD groups compared with controls. These results indicate that LBD and AD share the epsilon 4 allele of ApoE as a major risk factor for the development of disease and suggest a similarity in disease aetiology.

引用

页码：45 / 46

页数：2

共 14 条

[1] DIFFUSE LEWY BODY DISEASE - CLINICAL-FEATURES IN 15 CASES [J].