EFFECT OF PGE IN MULTIPLE EXPERIMENTAL-MODELS .9. IN-VIVO EFFECTS OF PGE ON IMMUNE-RESPONSE OF LEUKOCYTES TO WOUNDS

被引：5

作者：

DONG, YL ^{[1
]}

HERNDON, DN ^{[1
]}

YAN, TZ ^{[1
]}

WAYMACK, JP ^{[1
]}

机构：

[1] US FDA,DIV MED IMAGING SURG DENT PROD,HFD-160,5600 FISHERS LANE,ROCKVILLE,MD 20857

来源：

BURNS | 1994年 / 20卷 / 02期

关键词：

D O I：

10.1016/S0305-4179(06)80010-0

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

There have been conflicting results obtained when comparing the in vitro with in vivo effects of prostaglandin E (PGE) on immune function. The in vitro studies have demonstrated immune suppression with PGE administration while the in vivo studies demonstrated improved survival when utilizing infected models. To attempt to resolve this discrepancy, we evaluated the in vivo effect of PGE on host immune function utilizing multiple rat models. PGE was found to have no effect on the ability of leucocytes to infiltrate a sponge matrix wound over a 2-week period of study. PGE also failed to alter the percentage of T-lymphocyte subset populations infiltrating the sponge matrix model. There was noted to be no effect of PGE on the ability of neutrophils to chemiluminesce, or on metabolic function of lymphocytes. In conclusion, PGE does not appear to have immunosuppressive properties when studied using certain in vivo models.

引用

页码：132 / 135

页数：4

共 17 条

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