SYNTHESIS OF 2-ACETAMIDO-1,4-IMINO-1,2,4-TRIDEOXY-D-GALACTITOL AND COMPETITIVE-INHIBITION OF HUMAN LYSOSOMAL BETA-HEXAMINIDASE-A

被引：14

作者：

LIESSEM, B

GIANNIS, A

SANDHOFF, K

NIEGER, M

机构：

[1] UNIV BONN,INST ORGAN CHEM & BIOCHEM,D-53121 BONN,GERMANY

[2] UNIV BONN,INST ANORGAN CHEM,D-53121 BONN,GERMANY

来源：

CARBOHYDRATE RESEARCH | 1993年 / 250卷 / 01期

关键词：

D O I：

10.1016/0008-6215(93)84151-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of 2-acetamido-1,4-imino-1,2,4-trideoxy-D-galactitol (1; 2-acetamido-4-amino-1,4-anhydro-2,4-dideoxy-D-galactitol) by two different routes starting from 2-acetamido-2-deoxy-D-glucose is described. Compound 1 is a competitive inhibitor of human lysosomal beta-hexosaminidase A with K-i values of 18 mu M (beta-subunit) and 220 mu M (alpha-subunit). Similiar properties were found for the already known 2-acetamido-2-deoxy-D-gluco-hydroximo-1,4-lactone.

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页码：19 / 30

页数：12

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