SUBSTITUTED TETRALINS .I. SYNTHESIS AND ANALGESIC ACTIVITIES OF SOME 2-AMINOTETRALINS

被引：30

作者：

MARTIN, AR

PARULKAR, AP

GUSSECK, DJ

ANDERSON, LJ

GRUNEWALD, GL

WHITE, AI

机构：

[1] College of Pharmacy, Washington State University, Pullman, Washington

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 03期

关键词：

2‐Aminotetralins—synthesis; Analgesic activity—2‐aminotetralins; IR spectrophotometry—identity; NMR spectroscopy—identity; UV spectrophotometry—identity;

D O I：

10.1002/jps.2600580312

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of nine 4,4‐dimethyl‐2‐aminotetralins is described and their analgesic potencies are reported. One of the series, N,N‐dimethyl‐4,4‐dimethyl‐2‐naphthylamine, has an analgesic potency about two and one‐half times that of codeine or meperidine. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：340 / +

页数：1

共 33 条

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