SOLUBILITY IN AMIDE-WATER CO-SOLVENT SYSTEMS .2. CO-SOLVENT EXCESS AT SOLUTE SURFACE

被引：7

作者：

LINDSTROM, RE

机构：

[1] School of Pharmacy, University of Connecticut, Storrs, Connecticut

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 09期

关键词：

Amide‐water cosolvent systems—methylparaben solubility; cosolvent excess; Methylparaben—solubility in amide‐water cosolvent systems; Solubility—methylparaben in amide‐water cosolvent systems;

D O I：

10.1002/jps.2600680922

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The solubility of methylparaben was determined at 25° in a series of amide‐water cosolvent systems. The data were used to demonstrate the possibility of an amide excess at or near the ester solute over that in the bulk solvent. The analysis, stemming from an interfacial tension‐solute area solubility model proposed by earlier workers, involved data obtained as a function of amide concentration and as a function of amide alkylation. Both sets of data support the basic contention of the paper. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1141 / 1143

页数：3

共 16 条

[1] SOLUBILITY OF NONELECTROLYTES IN POLAR-SOLVENTS .2. SOLUBILITY OF ALIPHATIC-ALCOHOLS IN WATER [J].