PORPHYRIN SENSITIZERS IN TUMOR PHOTOTHERAPY - NOVEL SENSITIZERS OF THE CHLORIN AND BACTERIOCHLORIN CLASS WITH AMPHIPHILIC PROPERTIES

被引：34

作者：

BONNETT, R ^{[1
]}

NIZHNIK, AN ^{[1
]}

WHITE, SG ^{[1
]}

BERENBAUM, MC ^{[1
]}

机构：

[1] ST MARYS HOSP, SCH MED, DEPT EXPTL PATHOL, LONDON W2 1PG, ENGLAND

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 1990年 / 6卷 / 1-2期

关键词：

bacteriochlorins; chlorins; Photodynamic therapy; phthalocyanines; tumour photosensitization;

D O I：

10.1016/1011-1344(90)85071-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The requirements for activity in a tumour-photosensitizing drug are outlined. A series of metallo tetrasulphonatophthalocyanines are shown to be inactive in an in vivo assay of tumour photosensitization; however, some less water-soluble compounds (hydroxylated derivatives of octaethylchlorin and octaethylbacteriochlorin) are shown to possess promising activity. © 1990.

引用

页码：29 / 37

页数：9

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