THE MCK ENHANCER CONTAINS A P53 RESPONSIVE ELEMENT

被引：222

作者：

WEINTRAUB, H ^{[1
]}

HAUSCHKA, S ^{[1
]}

TAPSCOTT, SJ ^{[1
]}

机构：

[1] UNIV WASHINGTON,DEPT BIOCHEM,SEATTLE,WA 98195

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 11期

关键词：

P53; ANTIONCOGENE; TRANSACTIVATION;

D O I：

10.1073/pnas.88.11.4570

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

p53 is an antioncogene that is defective or absent in a large number of human tumors. Its function in normal cells is not known. We show that co-transfection of mouse p53 with muscle-specific creatine kinase-chloramphenicol acetyltransferase reporter gene, containing 3.3 kilobase of upstream control sequence for the muscle-specific creatine kinase gene, results in a 10- to 80-fold activation. The p53 responsive element maps to a region distinguished from the known MyoD binding region. Identification of a p53 responsive element should allow a more focused analysis of the effects of p53 in controlling gene activity.

引用

页码：4570 / 4571

页数：2

共 15 条

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