IMMUNOCOMPETENCE AND OXIDANT DEFENSE DURING ASCORBATE DEPLETION OF HEALTHY-MEN

被引:107
作者
JACOB, RA
KELLEY, DS
PIANALTO, FS
SWENDSEID, ME
HENNING, SM
ZHANG, JZ
AMES, BN
FRAGA, CG
PETERS, JH
机构
[1] UNIV CALIF LOS ANGELES, SCH PUBL HLTH, LOS ANGELES, CA 90024 USA
[2] UNIV CALIF BERKELEY, DEPT BIOCHEM, BERKELEY, CA 94720 USA
[3] SRI INT, DIV LIFE SCI, MENLO PK, CA 94025 USA
关键词
ASCORBATE; ASCORBIC ACID; VITAMIN-C; IMMUNOCOMPETENCE; IMMUNE FUNCTION; ANTIOXIDANT; FREE RADICALS; OXIDANT DAMAGE; MUTAGENS;
D O I
10.1093/ajcn/54.6.1302s
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
To determine nonscorbutic effects of moderate vitamin C deficiency we measured immune function and oxidative damage in eight healthy men (25-43 y) who consumed 5-250 mg/d of ascorbic acid over 92 d on a metabolic unit. During ascorbic acid intakes of 5, 10, or 20 mg/d, subjects attained a state of moderate ascorbic acid deficiency as ascorbic acid concentrations in plasma, leucocytes, semen, and buccal cells dropped to < 50% of baseline with no scorbutic symptoms observed. No changes in cell proliferation, erythrocyte antioxidant enzymes, and DNA strand breaks were observed; however, blood levels of glutathione and NAD(P) decreased during ascorbic acid deficiency, as did delayed hypersensitivity responsiveness. Concentrations of the oxidatively modified DNA base, 8-hydroxydeoxyguanosine in sperm DNA and fecapentaenes, ubiquitous fecal mutagens, were increased during ascorbic acid depletion. Moderate vitamin C deficiency, in the absence of scurvy, results in alteration of antioxidant chemistries and may permit increased oxidative damage.
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页码:S1302 / S1309
页数:8
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