LOCALIZATION OF IMMUNOGENIC DOMAINS IN THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-2 ENVELOPE

被引：15

作者：

HUANG, ML ^{[1
]}

ESSEX, M ^{[1
]}

LEE, TH ^{[1
]}

机构：

[1] HARVARD UNIV, SCH PUBL HLTH, DEPT CANC BIOL, 665 HUNTINGTON AVE, BOSTON, MA 02115 USA

来源：

JOURNAL OF VIROLOGY | 1991年 / 65卷 / 09期

关键词：

D O I：

10.1128/JVI.65.9.5073-5079.1991

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Highly immunogenic domains have not yet been defined in the extracellular protein of the human immunodeficiency virus type 2 (HIV-2) envelope. In this study, six contiguous segments covering the entire HIV-2ST envelope were amplified and cloned into a bacterial expression vector to localize the relative immunogenic reactivity of different regions of the molecule by Western blot (immunoblot) analysis. Our results demonstrate that the extracellular protein of the HIV-2 envelope contains highly immunogenic epitopes with potential value as type-specific markers for HIV-2 infection.

引用

页码：5073 / 5079

页数：7

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