NEW HEXAHYDROXYBIPHENYL DERIVATIVES AS INHIBITORS OF PROTEIN-KINASE-C

被引：55

作者：

KASHIWADA, Y

HUANG, L

BALLAS, LM

JIANG, JB

JANZEN, WP

LEE, KH

机构：

[1] UNIV N CAROLINA,SCH PHARM,DIV MED CHEM & NAT PROD,NAT PROD LAB,CHAPEL HILL,NC 27599

[2] SPHINX PHARMACEUT CORP,DURHAM,NC 27717

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1994年 / 37卷 / 01期

关键词：

D O I：

10.1021/jm00027a025

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have previously shown that some ellagitannins are potent inhibitors of protein kinase C (PKC). On the basis of this finding, several series of hexahydroxybiphenyl derivatives of ellagic acid were synthesized as simple analogs of these ellagitannins and were evaluated for their inhibitory effect against PKC. Compounds 23 and 26 were found to be potent inhibitors of PKC, while hexakis(benzyloxy)biphenyl derivatives exhibited weak anti-PKC activity.

引用

页码：195 / 200

页数：6

共 22 条

[1] SEQUENCE AND EXPRESSION OF HUMAN PROTEIN KINASE-C-EPSILON [J].

BASTA, P ;

STRICKLAND, MB ;

HOLMES, W ;

LOOMIS, CR ;

BALLAS, LM ;

BURNS, DJ .

BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1132 (02) :154-160

[2] EFFECTS OF ACTIVATORS OF PROTEIN-KINASE C, INCLUDING BRYOSTATIN-1 AND BRYOSTATIN-2, ON THE GROWTH OF A549 HUMAN-LUNG CARCINOMA-CELLS [J].

DALE, IL ;

GESCHER, A .

INTERNATIONAL JOURNAL OF CANCER, 1989, 43 (01) :158-163

[3]

GESCHER A, 1989, ANTI-CANCER DRUG DES, V4, P93

[4] SYNERGISM BETWEEN DIACYLGLYCEROLS AND CALCIUM IONOPHORE IN THE INDUCTION OF HUMAN B-CELL PROLIFERATION MIMICS THE INOSITOL LIPID POLYPHOSPHATE BREAKDOWN SIGNALS INDUCED BY CROSSLINKING SURFACE-IMMUNOGLOBULIN [J].

GUY, GR ;

GORDON, J ;

MICHELL, RH ;

BROWN, G .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1985, 131 (01) :484-491

[5]

HALENDA SP, 1985, J BIOL CHEM, V260, P2484

[6]

HANNUN YA, 1986, J BIOL CHEM, V261, P2604

[7]

INSOLE JM, 1990, J CHEM RES, P378

[8]

INSOLE JM, 1990, J CHEM RES M, P2831

[9]

KAIBUCHI K, 1985, J BIOL CHEM, V260, P1366

[10] TANNINS AS SELECTIVE INHIBITORS OF PROTEIN-KINASE-C [J].

KASHIWADA, Y ;

NONAKA, GI ;

NISHIOKA, I ;

BALLAS, LM ;

JIANG, JB ;

JANZEN, WP ;

LEE, KH .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1992, 2 (03) :239-244

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