INDOCYANINE GREEN-ENHANCED DIODE-LASER TREATMENT OF MELANOMA IN A RABBIT MODEL

被引：34

作者：

CHONG, LP

OZLER, SA

DEQUEIROZ, JM

LIGGETT, PE

机构：

[1] The Doheny Eye Institute and the Department of Ophthalmology, University of Southern California, Los Angeles, CA

[2] Department of Ophthalmology, Yale University, New Haven, CT

来源：

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 1993年 / 13卷 / 03期

关键词：

DIODE; INDOCYANINE GREEN; LASER; MELANOMA; PHOTOCOAGULATION;

D O I：

10.1097/00006982-199313030-00012

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Indocyanine green (ICG)-enhanced laser therapy was evaluated for the treatment of experimental intraocular melanoma. Immediately after an intravenous injection of ICG, a 790-nm chromophore, 810-nm semiconductor diode laser was used to irradiate Greene hamster melanomas that had been implanted in the iris of rabbits. ICG-enhanced laser treatment of melanoma (14 eyes) was compared with treatment by laser alone (4 eyes), ICG alone (1 eye), and no treatment (2 eyes). Tumors treated with ICG-enhanced laser showed no growth after treatment, as judged by clinical examination and photography. Histologically, 4 of the 14 tumors treated with ICG-enhanced laser showed total necrosis, whereas the remaining 10 tumors treated similarly demonstrated only rare viable cells around blood vessels or at the tumor periphery. Laser treatment without ICG enhancement resulted in only superficial tumor necrosis, and all four of these tumors continued to grow after treatment. With further evaluation, indocyanine green in combination with a commercially available diode laser may be useful in the treatment of ocular melanoma.

引用

页码：251 / 259

页数：9

共 50 条

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