PHAGE DISPLAY

被引:42
作者
BURTON, DR [1 ]
机构
[1] Scripps Res Inst, DEPT IMMUNOL & MOLEC BIOL, LA JOLLA, CA 92037 USA
来源
IMMUNOTECHNOLOGY | 1995年 / 1卷 / 02期
基金
美国国家卫生研究院;
关键词
HUMAN ANTIBODIES; VIRUS NEUTRALIZATION; IMMUNOTHERAPY VACCINES; PEPTIDE LIBRARIES;
D O I
10.1016/1380-2933(95)00013-5
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Phage display is a powerful method for the selection and evolution of proteins and peptides. Applications include the generation of potent and novel antibodies, the in vitro improvement of protein affinity and function, epitope discovery, the development of leads for vaccine research and the identification of interacting proteins using cDNA libraries.
引用
收藏
页码:87 / 94
页数:8
相关论文
共 98 条
  • [1] AKAMATSU Y, 1993, J IMMUNOL, V151, P4651
  • [2] Barbas Carlos F. Iii, 1993, Current Opinion in Biotechnology, V4, P526, DOI 10.1016/0958-1669(93)90072-5
  • [3] SEMISYNTHETIC COMBINATORIAL ANTIBODY LIBRARIES - A CHEMICAL SOLUTION TO THE DIVERSITY PROBLEM
    BARBAS, CF
    BAIN, JD
    HOEKSTRA, DM
    LERNER, RA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (10) : 4457 - 4461
  • [4] HUMAN MONOCLONAL FAB FRAGMENTS DERIVED FROM A COMBINATORIAL LIBRARY BIND TO RESPIRATORY SYNCYTIAL VIRUS-F GLYCOPROTEIN AND NEUTRALIZE INFECTIVITY
    BARBAS, CF
    CROWE, JE
    CABABA, D
    JONES, TM
    ZEBEDEE, SL
    MURPHY, BR
    CHANOCK, RM
    BURTON, DR
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) : 10164 - 10168
  • [5] IN-VITRO EVOLUTION OF A NEUTRALIZING HUMAN-ANTIBODY TO HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 TO ENHANCE AFFINITY AND BROADEN STRAIN CROSS-REACTIVITY
    BARBAS, CF
    HU, D
    DUNLOP, N
    SAWYER, L
    CABABA, D
    HENDRY, RM
    NARA, PL
    BURTON, DR
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (09) : 3809 - 3813
  • [6] ASSEMBLY OF COMBINATORIAL ANTIBODY LIBRARIES ON PHAGE SURFACES - THE GENE-III SITE
    BARBAS, CF
    KANG, AS
    LERNER, RA
    BENKOVIC, SJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (18) : 7978 - 7982
  • [7] RECOMBINANT HUMAN FAB FRAGMENTS NEUTRALIZE HUMAN TYPE-1 IMMUNODEFICIENCY VIRUS INVITRO
    BARBAS, CF
    BJORLING, E
    CHIODI, F
    DUNLOP, N
    CABABA, D
    JONES, TM
    ZEBEDEE, SL
    PERSSON, MAA
    NARA, PL
    NORRBY, E
    BURTON, DR
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (19) : 9339 - 9343
  • [8] HIGH-AFFINITY SELF-REACTIVE HUMAN-ANTIBODIES BY DESIGN AND SELECTION - TARGETING THE INTEGRIN LIGAND-BINDING SITE
    BARBAS, CF
    LANGUINO, LR
    SMITH, JW
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (21) : 10003 - 10007
  • [9] MOLECULAR PROFILE OF AN ANTIBODY-RESPONSE TO HIV-1 AS PROBED BY COMBINATORIAL LIBRARIES
    BARBAS, CF
    COLLET, TA
    AMBERG, W
    ROBEN, P
    BINLEY, JM
    HOEKSTRA, D
    CABABA, D
    JONES, TM
    WILLIAMSON, RA
    PILKINGTON, GR
    HAIGWOOD, NL
    CABEZAS, E
    SATTERTHWAIT, AC
    SANZ, I
    BURTON, DR
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1993, 230 (03) : 812 - 823
  • [10] HUMAN AUTOANTIBODY RECOGNITION OF DNA
    BARBAS, SM
    DITZEL, HJ
    SALONEN, EM
    YANG, WP
    SILVERMAN, GJ
    BURTON, DR
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (07) : 2529 - 2533