A STUDY OF THE USE OF NH4I FOR THE REDUCTION OF METHIONINE SULFOXIDE IN PEPTIDES CONTAINING CYSTEINE AND CYSTINE

被引：53

作者：

NICOLAS, E ^{[1
]}

VILASECA, M ^{[1
]}

GIRALT, E ^{[1
]}

机构：

[1] UNIV BARCELONA, DEPT QUIM ORGAN, E-08028 BARCELONA, SPAIN

来源：

TETRAHEDRON | 1995年 / 51卷 / 19期

关键词：

D O I：

10.1016/0040-4020(95)00234-Y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Methionine sulfoxide reduction by NH4I has been studied in some disulfide containing peptides. In general, this reagent has proved to be effective in neat TFA at 0 degrees C, with the obtention of the unprotected peptides in more than 99% yields and without reduction of the disulfide bridge bond. The use of Me(2)S as an additive resulted in faster reactions and disulfide scrambling was not observed. Whereas the Acm group proved to be stable to the reaction conditions, unprotected cysteine containing peptides afforded the corresponding parallel dimers.

引用

页码：5701 / 5710

页数：10

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