CLONING AND EXPRESSION OF PROTEIN-TYROSINE PHOSPHATASE-LIKE PROTEIN-DERIVED FROM A RAT PHEOCHROMOCYTOMA CELL-LINE

被引：17

作者：

KAMBAYASHI, Y ^{[1
]}

TAKAHASHI, K ^{[1
]}

BARDHAN, S ^{[1
]}

INAGAMI, T ^{[1
]}

机构：

[1] VANDERBILT UNIV,SCH MED,DEPT BIOCHEM,NASHVILLE,TN 37232

来源：

BIOCHEMICAL JOURNAL | 1995年 / 306卷

关键词：

D O I：

10.1042/bj3060331

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel protein [designated protein tyrosine phosphatase-like protein (PTPLP)] which is distantly related to receptor-type protein tyrosine phosphatases (PTPases) was cloned from a rat pheochromocytoma cell line. The PTPLP was detected exclusively in the brain. Overexpression of the PTPLP decreased the basal PTPase activity of COS-7 cells for Raytide. These results suggest that PTPLP may function as a negative regulator of PTPases in neuronal tissues.

引用

页码：331 / 335

页数：5

共 37 条

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