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INTRADERMAL RECOMBINANT INTERLEUKIN-2 ENHANCES PERIPHERAL-BLOOD T-CELL RESPONSES TO MITOGEN AND ANTIGENS IN PATIENTS WITH LEPROMATOUS LEPROSY
被引:19
作者
:
CONVERSE, P
论文数:
0
引用数:
0
h-index:
0
机构:
ARMAUER HANSEN RES INST,ADDIS ABABA,ETHIOPIA
CONVERSE, P
OTTENHOFF, THM
论文数:
0
引用数:
0
h-index:
0
机构:
ARMAUER HANSEN RES INST,ADDIS ABABA,ETHIOPIA
OTTENHOFF, THM
TEKLEMARIAM, SW
论文数:
0
引用数:
0
h-index:
0
机构:
ARMAUER HANSEN RES INST,ADDIS ABABA,ETHIOPIA
TEKLEMARIAM, SW
HANCOCK, GE
论文数:
0
引用数:
0
h-index:
0
机构:
ARMAUER HANSEN RES INST,ADDIS ABABA,ETHIOPIA
HANCOCK, GE
DIETZ, M
论文数:
0
引用数:
0
h-index:
0
机构:
ARMAUER HANSEN RES INST,ADDIS ABABA,ETHIOPIA
DIETZ, M
BECXBLEUMINK, M
论文数:
0
引用数:
0
h-index:
0
机构:
ARMAUER HANSEN RES INST,ADDIS ABABA,ETHIOPIA
BECXBLEUMINK, M
WONDIMU, A
论文数:
0
引用数:
0
h-index:
0
机构:
ARMAUER HANSEN RES INST,ADDIS ABABA,ETHIOPIA
WONDIMU, A
KIESSLING, R
论文数:
0
引用数:
0
h-index:
0
机构:
ARMAUER HANSEN RES INST,ADDIS ABABA,ETHIOPIA
KIESSLING, R
COHN, ZA
论文数:
0
引用数:
0
h-index:
0
机构:
ARMAUER HANSEN RES INST,ADDIS ABABA,ETHIOPIA
COHN, ZA
KAPLAN, G
论文数:
0
引用数:
0
h-index:
0
机构:
ARMAUER HANSEN RES INST,ADDIS ABABA,ETHIOPIA
KAPLAN, G
机构
:
[1]
ARMAUER HANSEN RES INST,ADDIS ABABA,ETHIOPIA
[2]
ROCKEFELLER UNIV,CELLULAR PHYSIOL & IMMUNOL LAB,NEW YORK,NY 10021
[3]
ALL AFRICAN LEPROSY REHABIL & TRAINING CTR,ADDIS ABABA,ETHIOPIA
来源
:
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
|
1990年
/ 32卷
/ 02期
关键词
:
D O I
:
10.1111/j.1365-3083.1990.tb02897.x
中图分类号
:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号
:
100102 ;
摘要
:
Thirty‐one patients with lepromatous leprosy received recombinant interleukin 2 (IL‐2) intradermally in doses ranging from 10 to 30 μg. Before injection and at time intervals of 2–21 days thereafter, samples of peripheral blood mononuclear cells (PBMC) were obtained. Single or multiple injections (1–3) of IL‐2 did not modify the total number of circulating lymphocytes or the number of T cells and the CD4/CD8 T‐cell ratio However. IL‐2 had a pronounced influence on the [3H]thymidine incorporation in response to various stimuli 4–8 days alter intradermal IL‐2. Stimulation indices of three‐ to sevenfold above pre‐IL‐2 levels were observed with the polyclonal activator phytohaemagglutinin (PHA) and enhanced thymidine incorporation occurred in the presence of antigens to which the patients were already sensitized, such as purified protein derivative and BCG. IL‐2 had no effect on the unresponsive stale of lepromatous leprosy patient T cells to the antigens of Mycobacterium leprae. Copyright © 1990, Wiley Blackwell. All rights reserved
引用
收藏
页码:83 / 91
页数:9
相关论文
共 24 条
[1]
BLOOM BR, 1983, REV INFECT DIS, V5, P765
[2]
CELLULAR, HUMORAL, AND GAMMA-INTERFERON RESPONSES TO MYCOBACTERIUM-LEPRAE AND BCG ANTIGENS IN HEALTHY-INDIVIDUALS EXPOSED TO LEPROSY
CONVERSE, PJ
论文数:
0
引用数:
0
h-index:
0
CONVERSE, PJ
OTTENHOFF, THM
论文数:
0
引用数:
0
h-index:
0
OTTENHOFF, THM
GEBRE, N
论文数:
0
引用数:
0
h-index:
0
GEBRE, N
EHRENBERG, JP
论文数:
0
引用数:
0
h-index:
0
EHRENBERG, JP
KIESSLING, R
论文数:
0
引用数:
0
h-index:
0
KIESSLING, R
[J].
SCANDINAVIAN JOURNAL OF IMMUNOLOGY,
1988,
27
(05)
: 515
-
525
[3]
INTERLEUKIN-2 (IL-2) AUGMENTS TRANSCRIPTION OF THE IL-2 RECEPTOR GENE
DEPPER, JM
论文数:
0
引用数:
0
h-index:
0
DEPPER, JM
LEONARD, WJ
论文数:
0
引用数:
0
h-index:
0
LEONARD, WJ
DROGULA, C
论文数:
0
引用数:
0
h-index:
0
DROGULA, C
KRONKE, M
论文数:
0
引用数:
0
h-index:
0
KRONKE, M
WALDMANN, TA
论文数:
0
引用数:
0
h-index:
0
WALDMANN, TA
GREENE, WC
论文数:
0
引用数:
0
h-index:
0
GREENE, WC
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1985,
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(12)
: 4230
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4234
[4]
GODAL T, 1971, CLIN EXP IMMUNOL, V9, P821
[5]
T-CELL CONDITIONED MEDIA REVERSE T-CELL UNRESPONSIVENESS IN LEPROMATOUS LEPROSY
HAREGEWOIN, A
论文数:
0
引用数:
0
h-index:
0
机构:
ALL AFRICA LEPROSY & REHABIL CTR,ADDIS ABABA,ETHIOPIA
HAREGEWOIN, A
GODAL, T
论文数:
0
引用数:
0
h-index:
0
机构:
ALL AFRICA LEPROSY & REHABIL CTR,ADDIS ABABA,ETHIOPIA
GODAL, T
MUSTAFA, AS
论文数:
0
引用数:
0
h-index:
0
机构:
ALL AFRICA LEPROSY & REHABIL CTR,ADDIS ABABA,ETHIOPIA
MUSTAFA, AS
BELEHU, A
论文数:
0
引用数:
0
h-index:
0
机构:
ALL AFRICA LEPROSY & REHABIL CTR,ADDIS ABABA,ETHIOPIA
BELEHU, A
YEMANEBERHAN, T
论文数:
0
引用数:
0
h-index:
0
机构:
ALL AFRICA LEPROSY & REHABIL CTR,ADDIS ABABA,ETHIOPIA
YEMANEBERHAN, T
[J].
NATURE,
1983,
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344
[6]
THE NATURE AND KINETICS OF A DELAYED IMMUNE-RESPONSE TO PURIFIED PROTEIN DERIVATIVE OF TUBERCULIN IN THE SKIN OF LEPROMATOUS LEPROSY PATIENTS
KAPLAN, G
论文数:
0
引用数:
0
h-index:
0
机构:
ALL INDIA INST MED SCI,NEW DELHI 110029,INDIA
KAPLAN, G
LAAL, S
论文数:
0
引用数:
0
h-index:
0
机构:
ALL INDIA INST MED SCI,NEW DELHI 110029,INDIA
LAAL, S
SHEFTEL, G
论文数:
0
引用数:
0
h-index:
0
机构:
ALL INDIA INST MED SCI,NEW DELHI 110029,INDIA
SHEFTEL, G
NUSRAT, A
论文数:
0
引用数:
0
h-index:
0
机构:
ALL INDIA INST MED SCI,NEW DELHI 110029,INDIA
NUSRAT, A
NATH, I
论文数:
0
引用数:
0
h-index:
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机构:
ALL INDIA INST MED SCI,NEW DELHI 110029,INDIA
NATH, I
MATHUR, NK
论文数:
0
引用数:
0
h-index:
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机构:
ALL INDIA INST MED SCI,NEW DELHI 110029,INDIA
MATHUR, NK
MISHRA, RS
论文数:
0
引用数:
0
h-index:
0
机构:
ALL INDIA INST MED SCI,NEW DELHI 110029,INDIA
MISHRA, RS
COHN, ZA
论文数:
0
引用数:
0
h-index:
0
机构:
ALL INDIA INST MED SCI,NEW DELHI 110029,INDIA
COHN, ZA
[J].
JOURNAL OF EXPERIMENTAL MEDICINE,
1988,
168
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DISTRIBUTION AND TURNOVER OF LANGERHANS CELLS DURING DELAYED IMMUNE-RESPONSES IN HUMAN-SKIN
KAPLAN, G
论文数:
0
引用数:
0
h-index:
0
机构:
ALL INDIA INST MED SCI,NEW DELHI 110016,INDIA
ALL INDIA INST MED SCI,NEW DELHI 110016,INDIA
KAPLAN, G
NUSRAT, A
论文数:
0
引用数:
0
h-index:
0
机构:
ALL INDIA INST MED SCI,NEW DELHI 110016,INDIA
ALL INDIA INST MED SCI,NEW DELHI 110016,INDIA
NUSRAT, A
WITMER, MD
论文数:
0
引用数:
0
h-index:
0
机构:
ALL INDIA INST MED SCI,NEW DELHI 110016,INDIA
ALL INDIA INST MED SCI,NEW DELHI 110016,INDIA
WITMER, MD
NATH, I
论文数:
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引用数:
0
h-index:
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机构:
ALL INDIA INST MED SCI,NEW DELHI 110016,INDIA
ALL INDIA INST MED SCI,NEW DELHI 110016,INDIA
NATH, I
COHN, ZA
论文数:
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引用数:
0
h-index:
0
机构:
ALL INDIA INST MED SCI,NEW DELHI 110016,INDIA
ALL INDIA INST MED SCI,NEW DELHI 110016,INDIA
COHN, ZA
[J].
JOURNAL OF EXPERIMENTAL MEDICINE,
1987,
165
(03)
: 763
-
776
[8]
KAPLAN G, 1987, J IMMUNOL, V138, P3028
[9]
EFFICACY OF A CELL-MEDIATED REACTION TO THE PURIFIED PROTEIN DERIVATIVE OF TUBERCULIN IN THE DISPOSAL OF MYCOBACTERIUM-LEPRAE FROM HUMAN-SKIN
KAPLAN, G
论文数:
0
引用数:
0
h-index:
0
机构:
GILLIS W LONG HANSENS DIS CTR,CARVILLE,LA 70721
KAPLAN, G
SHEFTEL, G
论文数:
0
引用数:
0
h-index:
0
机构:
GILLIS W LONG HANSENS DIS CTR,CARVILLE,LA 70721
SHEFTEL, G
JOB, CK
论文数:
0
引用数:
0
h-index:
0
机构:
GILLIS W LONG HANSENS DIS CTR,CARVILLE,LA 70721
JOB, CK
MATHUR, NK
论文数:
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引用数:
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h-index:
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机构:
GILLIS W LONG HANSENS DIS CTR,CARVILLE,LA 70721
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论文数:
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引用数:
0
h-index:
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机构:
GILLIS W LONG HANSENS DIS CTR,CARVILLE,LA 70721
NATH, I
COHN, ZA
论文数:
0
引用数:
0
h-index:
0
机构:
GILLIS W LONG HANSENS DIS CTR,CARVILLE,LA 70721
COHN, ZA
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1988,
85
(14)
: 5210
-
5214
[10]
AN ANALYSIS OF INVITRO T-CELL RESPONSIVENESS IN LEPROMATOUS LEPROSY
KAPLAN, G
论文数:
0
引用数:
0
h-index:
0
机构:
IRVINGTON HOUSE INST,NEW YORK,NY 10021
KAPLAN, G
WEINSTEIN, DE
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引用数:
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WEINSTEIN, DE
STEINMAN, RM
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IRVINGTON HOUSE INST,NEW YORK,NY 10021
STEINMAN, RM
LEVIS, WR
论文数:
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引用数:
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机构:
IRVINGTON HOUSE INST,NEW YORK,NY 10021
LEVIS, WR
ELVERS, U
论文数:
0
引用数:
0
h-index:
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机构:
IRVINGTON HOUSE INST,NEW YORK,NY 10021
ELVERS, U
PATARROYO, ME
论文数:
0
引用数:
0
h-index:
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机构:
IRVINGTON HOUSE INST,NEW YORK,NY 10021
PATARROYO, ME
COHN, ZA
论文数:
0
引用数:
0
h-index:
0
机构:
IRVINGTON HOUSE INST,NEW YORK,NY 10021
COHN, ZA
[J].
JOURNAL OF EXPERIMENTAL MEDICINE,
1985,
162
(03)
: 917
-
929
←
1
2
3
→
共 24 条
[1]
BLOOM BR, 1983, REV INFECT DIS, V5, P765
[2]
CELLULAR, HUMORAL, AND GAMMA-INTERFERON RESPONSES TO MYCOBACTERIUM-LEPRAE AND BCG ANTIGENS IN HEALTHY-INDIVIDUALS EXPOSED TO LEPROSY
CONVERSE, PJ
论文数:
0
引用数:
0
h-index:
0
CONVERSE, PJ
OTTENHOFF, THM
论文数:
0
引用数:
0
h-index:
0
OTTENHOFF, THM
GEBRE, N
论文数:
0
引用数:
0
h-index:
0
GEBRE, N
EHRENBERG, JP
论文数:
0
引用数:
0
h-index:
0
EHRENBERG, JP
KIESSLING, R
论文数:
0
引用数:
0
h-index:
0
KIESSLING, R
[J].
SCANDINAVIAN JOURNAL OF IMMUNOLOGY,
1988,
27
(05)
: 515
-
525
[3]
INTERLEUKIN-2 (IL-2) AUGMENTS TRANSCRIPTION OF THE IL-2 RECEPTOR GENE
DEPPER, JM
论文数:
0
引用数:
0
h-index:
0
DEPPER, JM
LEONARD, WJ
论文数:
0
引用数:
0
h-index:
0
LEONARD, WJ
DROGULA, C
论文数:
0
引用数:
0
h-index:
0
DROGULA, C
KRONKE, M
论文数:
0
引用数:
0
h-index:
0
KRONKE, M
WALDMANN, TA
论文数:
0
引用数:
0
h-index:
0
WALDMANN, TA
GREENE, WC
论文数:
0
引用数:
0
h-index:
0
GREENE, WC
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1985,
82
(12)
: 4230
-
4234
[4]
GODAL T, 1971, CLIN EXP IMMUNOL, V9, P821
[5]
T-CELL CONDITIONED MEDIA REVERSE T-CELL UNRESPONSIVENESS IN LEPROMATOUS LEPROSY
HAREGEWOIN, A
论文数:
0
引用数:
0
h-index:
0
机构:
ALL AFRICA LEPROSY & REHABIL CTR,ADDIS ABABA,ETHIOPIA
HAREGEWOIN, A
GODAL, T
论文数:
0
引用数:
0
h-index:
0
机构:
ALL AFRICA LEPROSY & REHABIL CTR,ADDIS ABABA,ETHIOPIA
GODAL, T
MUSTAFA, AS
论文数:
0
引用数:
0
h-index:
0
机构:
ALL AFRICA LEPROSY & REHABIL CTR,ADDIS ABABA,ETHIOPIA
MUSTAFA, AS
BELEHU, A
论文数:
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引用数:
0
h-index:
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机构:
ALL AFRICA LEPROSY & REHABIL CTR,ADDIS ABABA,ETHIOPIA
BELEHU, A
YEMANEBERHAN, T
论文数:
0
引用数:
0
h-index:
0
机构:
ALL AFRICA LEPROSY & REHABIL CTR,ADDIS ABABA,ETHIOPIA
YEMANEBERHAN, T
[J].
NATURE,
1983,
303
(5915)
: 342
-
344
[6]
THE NATURE AND KINETICS OF A DELAYED IMMUNE-RESPONSE TO PURIFIED PROTEIN DERIVATIVE OF TUBERCULIN IN THE SKIN OF LEPROMATOUS LEPROSY PATIENTS
KAPLAN, G
论文数:
0
引用数:
0
h-index:
0
机构:
ALL INDIA INST MED SCI,NEW DELHI 110029,INDIA
KAPLAN, G
LAAL, S
论文数:
0
引用数:
0
h-index:
0
机构:
ALL INDIA INST MED SCI,NEW DELHI 110029,INDIA
LAAL, S
SHEFTEL, G
论文数:
0
引用数:
0
h-index:
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机构:
ALL INDIA INST MED SCI,NEW DELHI 110029,INDIA
SHEFTEL, G
NUSRAT, A
论文数:
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引用数:
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ALL INDIA INST MED SCI,NEW DELHI 110029,INDIA
NUSRAT, A
NATH, I
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ALL INDIA INST MED SCI,NEW DELHI 110029,INDIA
NATH, I
MATHUR, NK
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机构:
ALL INDIA INST MED SCI,NEW DELHI 110029,INDIA
MATHUR, NK
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机构:
ALL INDIA INST MED SCI,NEW DELHI 110029,INDIA
MISHRA, RS
COHN, ZA
论文数:
0
引用数:
0
h-index:
0
机构:
ALL INDIA INST MED SCI,NEW DELHI 110029,INDIA
COHN, ZA
[J].
JOURNAL OF EXPERIMENTAL MEDICINE,
1988,
168
(05)
: 1811
-
1824
[7]
DISTRIBUTION AND TURNOVER OF LANGERHANS CELLS DURING DELAYED IMMUNE-RESPONSES IN HUMAN-SKIN
KAPLAN, G
论文数:
0
引用数:
0
h-index:
0
机构:
ALL INDIA INST MED SCI,NEW DELHI 110016,INDIA
ALL INDIA INST MED SCI,NEW DELHI 110016,INDIA
KAPLAN, G
NUSRAT, A
论文数:
0
引用数:
0
h-index:
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机构:
ALL INDIA INST MED SCI,NEW DELHI 110016,INDIA
ALL INDIA INST MED SCI,NEW DELHI 110016,INDIA
NUSRAT, A
WITMER, MD
论文数:
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引用数:
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h-index:
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机构:
ALL INDIA INST MED SCI,NEW DELHI 110016,INDIA
ALL INDIA INST MED SCI,NEW DELHI 110016,INDIA
WITMER, MD
NATH, I
论文数:
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引用数:
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h-index:
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ALL INDIA INST MED SCI,NEW DELHI 110016,INDIA
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论文数:
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引用数:
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h-index:
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机构:
ALL INDIA INST MED SCI,NEW DELHI 110016,INDIA
ALL INDIA INST MED SCI,NEW DELHI 110016,INDIA
COHN, ZA
[J].
JOURNAL OF EXPERIMENTAL MEDICINE,
1987,
165
(03)
: 763
-
776
[8]
KAPLAN G, 1987, J IMMUNOL, V138, P3028
[9]
EFFICACY OF A CELL-MEDIATED REACTION TO THE PURIFIED PROTEIN DERIVATIVE OF TUBERCULIN IN THE DISPOSAL OF MYCOBACTERIUM-LEPRAE FROM HUMAN-SKIN
KAPLAN, G
论文数:
0
引用数:
0
h-index:
0
机构:
GILLIS W LONG HANSENS DIS CTR,CARVILLE,LA 70721
KAPLAN, G
SHEFTEL, G
论文数:
0
引用数:
0
h-index:
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机构:
GILLIS W LONG HANSENS DIS CTR,CARVILLE,LA 70721
SHEFTEL, G
JOB, CK
论文数:
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引用数:
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h-index:
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机构:
GILLIS W LONG HANSENS DIS CTR,CARVILLE,LA 70721
JOB, CK
MATHUR, NK
论文数:
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引用数:
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h-index:
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机构:
GILLIS W LONG HANSENS DIS CTR,CARVILLE,LA 70721
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h-index:
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机构:
GILLIS W LONG HANSENS DIS CTR,CARVILLE,LA 70721
NATH, I
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论文数:
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引用数:
0
h-index:
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机构:
GILLIS W LONG HANSENS DIS CTR,CARVILLE,LA 70721
COHN, ZA
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1988,
85
(14)
: 5210
-
5214
[10]
AN ANALYSIS OF INVITRO T-CELL RESPONSIVENESS IN LEPROMATOUS LEPROSY
KAPLAN, G
论文数:
0
引用数:
0
h-index:
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机构:
IRVINGTON HOUSE INST,NEW YORK,NY 10021
KAPLAN, G
WEINSTEIN, DE
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WEINSTEIN, DE
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IRVINGTON HOUSE INST,NEW YORK,NY 10021
STEINMAN, RM
LEVIS, WR
论文数:
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IRVINGTON HOUSE INST,NEW YORK,NY 10021
LEVIS, WR
ELVERS, U
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IRVINGTON HOUSE INST,NEW YORK,NY 10021
ELVERS, U
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0
机构:
IRVINGTON HOUSE INST,NEW YORK,NY 10021
PATARROYO, ME
COHN, ZA
论文数:
0
引用数:
0
h-index:
0
机构:
IRVINGTON HOUSE INST,NEW YORK,NY 10021
COHN, ZA
[J].
JOURNAL OF EXPERIMENTAL MEDICINE,
1985,
162
(03)
: 917
-
929
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