INTRADERMAL RECOMBINANT INTERLEUKIN-2 ENHANCES PERIPHERAL-BLOOD T-CELL RESPONSES TO MITOGEN AND ANTIGENS IN PATIENTS WITH LEPROMATOUS LEPROSY

被引:19
作者
CONVERSE, P
OTTENHOFF, THM
TEKLEMARIAM, SW
HANCOCK, GE
DIETZ, M
BECXBLEUMINK, M
WONDIMU, A
KIESSLING, R
COHN, ZA
KAPLAN, G
机构
[1] ARMAUER HANSEN RES INST,ADDIS ABABA,ETHIOPIA
[2] ROCKEFELLER UNIV,CELLULAR PHYSIOL & IMMUNOL LAB,NEW YORK,NY 10021
[3] ALL AFRICAN LEPROSY REHABIL & TRAINING CTR,ADDIS ABABA,ETHIOPIA
关键词
D O I
10.1111/j.1365-3083.1990.tb02897.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Thirty‐one patients with lepromatous leprosy received recombinant interleukin 2 (IL‐2) intradermally in doses ranging from 10 to 30 μg. Before injection and at time intervals of 2–21 days thereafter, samples of peripheral blood mononuclear cells (PBMC) were obtained. Single or multiple injections (1–3) of IL‐2 did not modify the total number of circulating lymphocytes or the number of T cells and the CD4/CD8 T‐cell ratio However. IL‐2 had a pronounced influence on the [3H]thymidine incorporation in response to various stimuli 4–8 days alter intradermal IL‐2. Stimulation indices of three‐ to sevenfold above pre‐IL‐2 levels were observed with the polyclonal activator phytohaemagglutinin (PHA) and enhanced thymidine incorporation occurred in the presence of antigens to which the patients were already sensitized, such as purified protein derivative and BCG. IL‐2 had no effect on the unresponsive stale of lepromatous leprosy patient T cells to the antigens of Mycobacterium leprae. Copyright © 1990, Wiley Blackwell. All rights reserved
引用
收藏
页码:83 / 91
页数:9
相关论文
共 24 条
  • [1] BLOOM BR, 1983, REV INFECT DIS, V5, P765
  • [2] CELLULAR, HUMORAL, AND GAMMA-INTERFERON RESPONSES TO MYCOBACTERIUM-LEPRAE AND BCG ANTIGENS IN HEALTHY-INDIVIDUALS EXPOSED TO LEPROSY
    CONVERSE, PJ
    OTTENHOFF, THM
    GEBRE, N
    EHRENBERG, JP
    KIESSLING, R
    [J]. SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1988, 27 (05) : 515 - 525
  • [3] INTERLEUKIN-2 (IL-2) AUGMENTS TRANSCRIPTION OF THE IL-2 RECEPTOR GENE
    DEPPER, JM
    LEONARD, WJ
    DROGULA, C
    KRONKE, M
    WALDMANN, TA
    GREENE, WC
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (12) : 4230 - 4234
  • [4] GODAL T, 1971, CLIN EXP IMMUNOL, V9, P821
  • [5] T-CELL CONDITIONED MEDIA REVERSE T-CELL UNRESPONSIVENESS IN LEPROMATOUS LEPROSY
    HAREGEWOIN, A
    GODAL, T
    MUSTAFA, AS
    BELEHU, A
    YEMANEBERHAN, T
    [J]. NATURE, 1983, 303 (5915) : 342 - 344
  • [6] THE NATURE AND KINETICS OF A DELAYED IMMUNE-RESPONSE TO PURIFIED PROTEIN DERIVATIVE OF TUBERCULIN IN THE SKIN OF LEPROMATOUS LEPROSY PATIENTS
    KAPLAN, G
    LAAL, S
    SHEFTEL, G
    NUSRAT, A
    NATH, I
    MATHUR, NK
    MISHRA, RS
    COHN, ZA
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 168 (05) : 1811 - 1824
  • [7] DISTRIBUTION AND TURNOVER OF LANGERHANS CELLS DURING DELAYED IMMUNE-RESPONSES IN HUMAN-SKIN
    KAPLAN, G
    NUSRAT, A
    WITMER, MD
    NATH, I
    COHN, ZA
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 165 (03) : 763 - 776
  • [8] KAPLAN G, 1987, J IMMUNOL, V138, P3028
  • [9] EFFICACY OF A CELL-MEDIATED REACTION TO THE PURIFIED PROTEIN DERIVATIVE OF TUBERCULIN IN THE DISPOSAL OF MYCOBACTERIUM-LEPRAE FROM HUMAN-SKIN
    KAPLAN, G
    SHEFTEL, G
    JOB, CK
    MATHUR, NK
    NATH, I
    COHN, ZA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (14) : 5210 - 5214
  • [10] AN ANALYSIS OF INVITRO T-CELL RESPONSIVENESS IN LEPROMATOUS LEPROSY
    KAPLAN, G
    WEINSTEIN, DE
    STEINMAN, RM
    LEVIS, WR
    ELVERS, U
    PATARROYO, ME
    COHN, ZA
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1985, 162 (03) : 917 - 929