ULTRASTRUCTURAL-STUDY ON THE EFFECTS OF WARM ISCHEMIA ON THE INOSINE-PROTECTED KIDNEY

被引：7

作者：

FERNANDO, AR

GUNTER, PA

HENDRY, WF

SMITH, AF

WATKINSON, LE

WICKHAM, JEA

机构：

[1] ST BARTHOLOMEWS HOSP,DEPT UROL,LONDON EC1A 7BE,ENGLAND

[2] ST PAUL HOSP,DEPT PATHOL,LONDON,ENGLAND

[3] INST UROL,LONDON,ENGLAND

来源：

BRITISH JOURNAL OF UROLOGY | 1979年 / 51卷 / 03期

关键词：

D O I：

10.1111/j.1464-410X.1979.tb02858.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Summary— Unperfused, saline‐perfused and inosine‐perfused rat kidneys were subjected to various times of warm ischaemia with and without resumption of blood flow. Tissues were examined with a transmission electron microscope. Inosine has a protective effect on the epithelial cells of the proximal convoluted tubules, where microvilli are less damaged by ischaemia than those of the proximal convoluted tubular cells of the control animals. There is also a much higher ratio of autophagic vacuoles to lysosomes present in cells of inosine‐treated kidneys, reflecting their ability to sequester and digest organelles damaged during ischaemia and thus protect themselves from degradation products. A major effect of inosine seems to be the preservation of the organelles and brush border of the cells of the proximal tubule during warm ischaemia. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：167 / 172

页数：6

共 7 条

[1]

Ericsson J. L. E., 1969, LYSOSOMES BIOLOGY PA, V2, P345

[2] PROTECTIVE EFFECT OF INOSINE ON CANINE KIDNEY DURING ISCHEMIA AT 37C [J].