EFFECT OF PHENOBARBITAL ON CEREBRAL ENERGY-STATE AND METABOLISM - ENZYMATIC-ACTIVITIES

被引：11

作者：

BENZI, G

AGNOLI, A

DAGANI, F

RUGGIERI, S

VILLA, RF

机构：

[1] UNIV PAVIA, INST PHARMACOL, DEPT SCI, I-27100 PAVIA, ITALY

[2] UNIV AQUILA, DEPT NEUROL, AQUILA, ITALY

来源：

STROKE | 1979年 / 10卷 / 06期

关键词：

D O I：

10.1161/01.STR.10.6.733

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The changes induced by phenobarbital in cerebral enzymatic activities of the Krebs'' cycle (citrate synthase (EC 4.1.3.7), malate dehydrogenase (EC 1.1.1.37)) and electron transfer chain (total NADH-cytochrome c reductase (EC 1.6.99.3) and cytochrome oxidase) were studied. In addition, the activity of lactate dehydrogenase of acetylcholine esterase (EC 3.1.1.7) and of glutamate dehydrogenase (EC 1.4.1.3) was also studied. These enzymatic activities were evaluated in the homogenate in toto and in a crude mitochondrial fraction from rat brain. The modifications in some of these activities indicate that several new metabolic situations occur in brain tissue after phenobarbital treatment.

引用

页码：733 / 735

页数：3

共 16 条

[1] BARBITURATES AND OXIDATIVE PHOSPHORYLATION [J].