INHIBITION OF ENDOPROTEOLYTIC CLEAVAGE OF CYTOMEGALOVIRUS (HCMV) GLYCOPROTEIN-B BY PALMITOYL PEPTIDYL CHLOROMETHYL KETONE

被引：15

作者：

BRUCHER, KH

GARTEN, W

KLENK, HD

SHAW, E

RADSAK, K

机构：

[1] UNIV MARBURG, INST VIROL, ROBERT KOCH STR 17, W-3550 MARBURG, GERMANY

[2] FRIEDRICH MIESCHER INST, CH-4002 BASEL, SWITZERLAND

来源：

VIROLOGY | 1990年 / 178卷 / 02期

关键词：

D O I：

10.1016/0042-6822(90)90365-X

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Endoproteolytic cleavage of glycoprotein B (gB) of human cytomegalovirus (HCMV) is inhibited by palmitoylated peptidyl-chloromethyl ketone (palFAKR-CEK) at concentrations above 30 μM. Inhibitor treatment of HCMV-infected human fibroblasts neither interfered with exposure of gB on the plasma membrane, detected by surface membrane immunostaining, nor reduced production of intracellular infectious viral progeny. Release of infectious virus, on the other hand, was impaired. © 1990.

引用

页码：617 / 620

页数：4

共 18 条

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