ASCORBIC-ACID AND INSITU KINETICS - A NEW APPROACH TO VITAMIN REQUIREMENTS

被引：36

作者：

LEVINE, M ^{[1
]}

DHARIWAL, KR ^{[1
]}

WASHKO, PW ^{[1
]}

BUTLER, JD ^{[1
]}

WELCH, RW ^{[1
]}

WANG, YH ^{[1
]}

BERGSTEN, P ^{[1
]}

机构：

[1] NICHHD, HUMAN GENET BRANCH, BETHESDA, MD 20892 USA

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 1991年 / 54卷 / 06期

关键词：

INSITU KINETICS; ASCORBIC ACID; NOREPINEPHRINE SYNTHESIS;

D O I：

10.1093/ajcn/54.6.1157s

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Ascorbic acid requirements are based on preventing the deficiency disease scurvy and on urinary excretion of vitamin C. We proposed the first quantitative approach to determining optimal requirements for ascorbic acid and other vitamins, called in situ kinetics. In situ kinetics biochemically is based on the application of Michaelis-Menten reaction kinetics to ascorbic acid-dependent reactions in situ. Clinically in situ kinetics is based on determining vitamin availability to tissues, so that cell-specific reactions can occur. The biochemical concepts of in situ kinetics are verified for the first time through studying ascorbic acid regulation of norepinephrine biosynthesis. The principles of in situ kinetics can now be applied to humans and human cells and for determining optimal requirements for ascorbic acid and for other vitamins.

引用

页码：S1157 / S1162

页数：6

共 42 条

[1]

BAKER EM, 1971, AM J CLIN NUTR, V24, P444

[2]

BAKER EM, 1969, AM J CLIN NUTR, V22, P549

[3] TISSUE FRACTIONATION AND CATECHOLAMINES .I. LATENCY AND ACTIVATION PROPERTIES OF DOPAMINE-BETA-HYDROXYLASE IN ADRENAL MEDULLA [J].