INCREASED NUMBERS OF T-CELLS RECOGNIZING MULTIPLE MYELIN BASIC-PROTEIN EPITOPES IN MULTIPLE-SCLEROSIS

被引:102
作者
OLSSON, T
SUN, JB
HILLERT, J
HOJEBERG, B
EKRE, HP
ANDERSSON, G
OLERUP, O
LINK, H
机构
[1] KAROLINSKA INST,HUDDINGE UNIV HOSP,CTR BIOTECHNOL,S-14186 HUDDINGE,SWEDEN
[2] KABI BIOPHARMA,RES & DEV IMMUNOBIOL,STOCKHOLM,SWEDEN
关键词
D O I
10.1002/eji.1830220431
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Myelin basic protein (MBP)-autoreactive T cells have a crucial pathogenetic role in experimental allergic encephalomyelitis (EAE) and certain MBP epitopes may be immunodominantly recognized. The heterogeneity and quantity of the T cell response to different epitopes of MBP in multiple sclerosis (MS) and non-MS controls is not so clearly defined. We now study T cell reactivity to six different peptides of MBP in MS compared to controls in short-term cultures of blood mononuclear cells by measuring numbers of T cells that secrete interferon-gamma in response to antigen. In comparison with controls, MS patients showed dramatically increased numbers of MBP peptide-reactive T cells with mean values varying between 10.4 and 22.5 per 10(5) blood mononuclear cells. Among those MBP peptides examined (amino acid 1-20, 63-88, 89-101, 96-118, 110-128 and 148-165), no single peptide is preferentially recognized. Neither is any preferential response apparent after subdivision of the MS patients according to their HLA-DR genotype. Our findings suggest that a quantitative increase of a broad repertoire of myelin-autoreactive T cells with capacity to secrete IFN-gamma can be important for the pathogenesis of MS.
引用
收藏
页码:1083 / 1087
页数:5
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