CHARACTERISTICS RELATING TO OVARIAN-CANCER RISK - COLLABORATIVE ANALYSIS OF 12 UNITED-STATES CASE-CONTROL STUDIES .6. NONEPITHELIAL CANCERS AMONG ADULTS

被引：47

作者：

HORNROSS, PL

WHITTEMORE, AS

HARRIS, R

ITNYRE, J

机构：

[1] Northern California Cancer Center, Union City, CA

[2] Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA

[3] Department of Preventive Medicine, University of Southern California, Los Angeles, CA

[4] Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Boston, MA

[5] Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD

[6] Department of Health Research and Policy, Stanford University, Stanford, CA

[7] Department of Epidemiology, University of California, San Francisco, CA

[8] Division of Reproductive Health, Women’s Health and Fertility Branch, Centers for Disease Control, Atlanta, GA

[9] Department of Family and Community Medicine, University of Utah Medicai Center, Salt Lake City, UT

[10] Department of Social and Preventive Medicine, SUNY Buffalo School of Medicine, Buffalo, NY

[11] Department of Obstetrics and Gynecology, George Washington University Medicai Center, Washington, DC

[12] Bureau of Chronic Diseases, Cancer Control Program, New York State Department of Health, Albany, NY

[13] Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA

[14] Sione Epidemiology Unit, School of Public Health, Boston University School of Medicine, Boston, MA

[15] Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA

[16] Extramural Programs, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD

来源：

EPIDEMIOLOGY | 1992年 / 3卷 / 06期

关键词：

NONEPITHELIAL OVARIAN NEOPLASMS; GERM CELL NEOPLASMS; SEX CORD-STROMAL NEOPLASMS; PREGNANCY; ORAL CONTRACEPTIVES; PARITY; ADULTS;

D O I：

10.1097/00001648-199211000-00005

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Nonepithelial ovarian cancers are rare, and little is known about their etiology. Of particular interest are the effects of oral contraceptive use and pregnancy, both of which are associated with large decreases in risk for epithelial ovarian cancer. We examined the risk factors for nonepithelial ovarian tumors by combining data from four case-control studies conducted in the United States. We compared personal characteristics of 38 germ cell cases and 45 stromal cases, respectively, with 1,142 and 2,617 general population controls. All subjects were over age 18 years. For germ cell tumors, there was a weak negative association with parity but no consistent pattern of decreasing risk with increasing parity. In contrast, relative to nulligravid women, gravid nulliparous women were at increased risk of developing a germ ce cancer [odds ratio (OR) = 4.8, 95% confidence interval (CI) = 1.2-18.61. The use of oral contraceptives was also associated with elevated risk (OR = 2.0,95% CI = 0.77-5.1); however, no clear trends in risk were observed. For stromal tumors, oral contraceptive use was associated with decreased risk (OR = 0.37, 95% CI = 0.16-0.83), whereas pregnancy was associated with a small elevation in risk. A trend of increasing risk with increasing age at first term pregnancy was observed, with an odds ratio of 3.6 (95% CI = 1.0-12.5) for a first birth after age 29 years. Risk factors' for nonepithelial ovarian cancers do not appear to parallel each other or those for epithelial ovarian cancer.

引用

页码：490 / 495

页数：6

共 16 条

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