DISTRIBUTION OF NERVE GROWTH FACTOR-LIKE PROTEIN AND NERVE GROWTH-FACTOR RECEPTOR IN HUMAN BENIGN PROSTATIC HYPERPLASIA AND PROSTATIC ADENOCARCINOMA

被引:83
作者
GRAHAM, CW
LYNCH, JH
DJAKIEW, D
机构
[1] GEORGETOWN UNIV,MED CTR,DEPT ANAT & CELL BIOL,WASHINGTON,DC 20007
[2] GEORGETOWN UNIV,MED CTR,DEPT SURG,DIV UROL,WASHINGTON,DC 20007
关键词
PROSTATE; GROWTH SUBSTANCES;
D O I
10.1016/S0022-5347(17)37590-0
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Recent observations from our laboratory have identified a nerve growth factor (NGF)-like protein in conditioned media of stromal cells and neoplastic epithelial cells of the human prostate which mediates paracrine interactive growth of both cell types in vitro. In order to investigate the location of this NGF-like protein in the human prostate in vivo, and whether a nerve growth factor receptor (NGF-R) could be identified, we have carried out immunocytochemical studies on frozen tissue sections of human benign prostatic hyperplasia (BPH), prostatic adenocarcinoma and normal prostatic tissue. The NGF-like protein localized predominantly to the stromal component of BPH, adenocarcinoma and normal (non-cancerous) prostatic tissue. Conversely, the NGF-R localized predominantly to the epithelial cells of these tissues. Renal tissue provided negative controls for both the NGF-like protein and the NGF-R. The testis provided positive controls for both the NGF-like protein and the NGF-R. These results provide corroborative evidence for a NGF-like protein produced by stromal cells which interacts with a NGF-R on the adjacent epithelial cells thereby mediating paracrine interactive growth regulation of the human prostate.
引用
收藏
页码:1444 / 1447
页数:4
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